The results showed that the anisotropy of the GCAWs depends on the coupling of magnetostriction and internal stresses, and can be tailored by varying the ratio of the glass coating layer thickness to the metal core radius because the ratio characterizes the stress in the ferromagnetic core. The larger the ratio, the smaller the angle between the easy axis of anisotropy and the circumferential direction. The results further showed that for a GCAW wire originally with helical anisotropy, shortening the length of the wire below a critical value 10 mm will change the anisotropy

from helical to circumferential, because the wire end domains form circumferential anisotropy. (C) 2011 American Institute of Physics. [doi:10.1063/1.3556684]“
“We report a three-step preparation find more of a polymer-supported oxidizing reagent, polyethylene-g-N-bromosuccinimide (PE-g-NBS), through the graft copolymerization of maleic anhydride (MAn) onto polyethylene (PE) by a photochemical method with 1% benzophenone as a photosensitizer.

The postgrafting treatment of polyethylene-g-maleic anhydride (PE-g-MAn) with urea on fusion gives polyethylene-g-succinimide (PE-g-succinimide), which, on further treatment selleck chemicals with an aqueous solution of sodium hydroxide and bromine, gives the required reagent, PE-g-NBS. The maximum percentage grafting (25%) was obtained with 3.57 mol of MAn and 0.5 mL of 1% benzophenone in 120 min. Fourier transform infrared spectroscopy and thermogravimetric analysis methods were used to characterize the graft copolymer PE-g-MAn, PE-g-succinimide, and the polymeric support, that is, PE-g-NBS. Transferase inhibitor The grafted PE and the polymeric support were found to be thermally stable. The polymer-supported N-bromosuccinimide was used successfully for the efficient oxidation of a series of alcohols, including 2-propanol, n-butanol, ethylene glycol, cyclohexanol,

poly(vinyl alcohol), benzoin, benzyl alcohol, and chloromycetin, to their corresponding aldehydes and ketones. The selectivity of PE-g-NBS toward the oxidation of secondary alcoholic groups without the disturbance of the primary alcoholic groups was reflected during the oxidation of chloromycetin. The oxidized products were characterized by Fourier transform infrared and (1)H-NMR spectral methods. The reagent was reused for the oxidation of fresh alcohols, and it was found to oxidize them successfully, although with a little lower product yield. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 2584-2590, 2011″
“In this study, the magnetic properties and crystalline behavior of Fe(84-x)B(10)C(6)Cu(x) (x – 0-1.3) alloys prepared by annealing the melt-spun ribbon have been investigated.

05). Our study has demonstrated a superior effect for HCSS therapy in patients with mild HSP disease, for MP therapy in patients with moderate disease, and for MP combined with TG therapy in patients with severe disease.

CA3 mouse MP therapy administered initially reduces the duration of urinary protein abnormality. The therapeutic protocols did not increase the risk of relapse and were safe.”
“The in vitro antifungal activity of chitosan against Fusarium oxysporum f. sp. cubense Race 4 (FocR4) the causal agent of banana wilt was investigated. Chitosan at all concentrations tested reduced the hyphal growth of FocR4 on potato dextrose agar media and recording maximum inhibition of 76.36% at 8 mg/mL. The inhibitory effect was found to increase as chitosan concentration increases. The 50% effective concentration

value was estimated by probit analysis, and it was 1.4 mg/mL. Chitosan was more effective in potato dextrose broth where it completely inhibited the mycelial growth of FocR4 at all concentrations tested. Chitosan inhibited the sporulation of FocR4 by a maximum of 96.53% at 8 mg/mL chitosan, and 100% inhibition for spore germination was recorded at all concentrations tested. Chitosan at concentrations of more than 1.6 mg/mL was also found to induce morphological changes in FocR4 characterized by agglomeration of hyphae, abnormal shapes, vesicles, or empty cells devoid of cytoplasm in the mycelia. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 2434-2439, 2011″
“Background: It is clear that the biologic characteristics of GSK690693 mouse gastric cancer are different on the basis of mucin phenotypes. However, there are unabated controversies on the exact biologic differences Apoptosis inhibitor of mucin expression in gastric cancer. Methods: We analyzed various protein expressions and microsatellite instability (MSI) status based on mucin expression

in 130 differentiated early gastric adenocarcinoma cases. Furthermore, we evaluated the genomic alternation in 10 selected differentiated early gastric adenocarcinoma cases using array based comparative genomic hybridization (aCGH). Results: Intestinal mucin predominant subtype showed significantly elevated p53 protein and caudal-related homeobox 2 expression, and delocalization of beta catenin expressions compared to the gastric mucin predominant subtype. On MSI status, the gastric mucin predominant subtype more frequently showed unstable status than the intestinal mucin predominant subtype. CGH study showed more frequent chromosomal gain and loss in the intestinal mucin predominant subtype than the gastric mucin predominant subtype, albeit without statistical significance. Interestingly, there were significant differences in chromosomal alternation between four mucin phenotypes. Conclusions: Study results suggest possible different points of biologic behaviors in early differentiated gastric adenocarcinomas by mucin expression type.

The separation efficiency for electron-hole HSP990 ic50 was enhanced

when alpha-Bi2O3 was doped with Pr. The photocatalytic activities, which were evaluated by degradation of Rhodamine B (RhB) and 2,4-dichlorophenol (2,4-DCP) under visible light irradiation, was enhanced significantly by doping Pr into alpha-Bi2O3.

CONCLUSION: Doping alpha-Bi2O3 with Pr significantly enhanced the photocatalytic activity. The optimum percentage of doped pr was 3.0 mol %. center dot OH radicals were the dominant photooxidant. This study demonstrates an efficient pathway to improve the photocatalytic performance of alpha-Bi2O3. (C) 2013 Society of Chemical Industry”
“Effect of B content on the magnetic properties, phase evolution, magnetic after effect, and the activation energy (E(a)) for the melt- spun [(Fe(0.7)Co(0.3))(0.725)Pt(0.275)](100-x)B(x) (x=14-18) ribbons has been investigated. Sufficient amount of boron addition effectively decreases the activation energy of ordering transformation, and also refines the grain size of the studied ribbons after thermal annealing, resulting in the improvement of (i)H(c) from 3.4 kOe for x=14 to 6.2 kOe for

x=18. The highest permanent magnetic properties of B(r)=10.1 kG, (i)H(c)=5.4 kOe, and (BH)(max)=15.7 MGOe can be achieved in [(Fe(0.7)Co(0.3))(0.725)Pt(0.275)](85)B(15) ribbons. Meanwhile, the magnetic after effect study evidences that the activation volume is reduced with the increase in B content from V=41.33×10(-19)

cm(3) for x=14 to V=21.71×10(-19) AC220 inhibitor cm(3) for x=18, arisen from the lower volume fraction of magnetically soft phases and the stronger exchange-coupling Etomoxir effect between magnetic grains. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3068466]“
“BACKGROUNDOligoamides containing intramolecular hydrogen bonds have proved to be excellent extractants for metal cations, but their polymeric counterparts have never been used. Thorium separation from rare earth elements has long been a research subject due to its importance in nuclear energy and metallurgy. In this work a novel polyaramide has been synthesized and investigated for solvent extraction and separation of thorium and rare earths.

RESULTSThe synthesized polymer 1 [(C32H46N2O6)(n)], shows a high extractability of 89.4% towards Th(IV) compared with only 36-48% for rare earths. The optimized pH value for extraction of Th(IV) was 3.97. At C-1/C-M = 2.0, the extraction for Th(IV) reached 95.1%. When adding NaNO3, the separation of Th(IV) from La(III) is more efficient than that from Eu(III) or Yb(III), especially at higher NaNO3 concentration. Th(IV) can be thoroughly stripped from organic phase at 1.50molL(-1) HNO3 concentration.

CONCLUSIONDirect condensation of aromatic diamine and diacid led to a novel polyaramide with introverted chelating groups.

Fluorescence emission of PFN solution (10 mu mol/L) can be drastically quenched to about one fourth of its original intensity in the presence of a trace amount (2.6 mu mol/L) of ssDNA. The effect of oligonucleotide length on the fluorescence quenching behavior was also investigated. In contrast to single-stranded DNA with 20 bases (ssDNA-20), ssDNA with 40 bases (ssDNA-40) induces a relatively higher quenching efficiency and larger red-shift of PFN emission maximum. The binding constant of ssDNA-20 and PFN is estimated to be 1.12 x 10(21). At extremely low concentration Etomoxir chemical structure (10 nmol/L), PFN can respond to 0.2 nmol/L (or 2 x 10(-10) mol/L) of ssDNA-20

by significant enhancement of its ML323 price emission intensity. The result is contrary to the observation in the relative higher concentration,

and its mechanism is postulated. Based on the high binding ability of ssDNA with cationic CPE, a label-free method for ssDNA detection is designed. It uses an electrostatic complex of cationic PFN and an anionic CPE, which exhibits fluorescence resonance energy transfer (FRET) between the two components. Addition of ssDNA improves the FRET extent, indicated by obvious change of fluorescence spectra of the conjugated polyelectrolyte complex. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 114: 1278-1286, 2009″
“We report the observation of nanoscale striped periodic pattern with similar distinctive characteristics independent of loading conditions on the fracture surface of various bulk metallic glasses. We demonstrate that the periodic stripes are formed by the orderly assembly of nanoscale regular dimples. The similarities between our observed striped pattern and various unequilibrium systems such as oscillating granular and colloidal suspensions systems are found. By drawing an analogy between glassy and granular materials, we propose a model that can capture and simulate the characteristics of the observed corrugations. Our results would Raf targets provide insight into the origin of fracture

surface roughening in brittle materials.”
“Background This study aims to explore differences in personal narratives of the experience of illness and treatment in depressed oncologic patients who received either combined treatment for depression (psychotherapy plus antidepressants) or standard treatment (antidepressants alone). Methods We employed a qualitative research design based on grounded theory. Data were collected from eight videotaped focus groups and semi-structured interviews with a total of 28 participants. The research team reviewed interview transcripts and categorized the participants’ responses using the ATLAS.ti (ATLAS.ti Scientific Software Development GmbH Hardenbergstr. 7 D-10623, Berlin) software package.

The results showed that M. indicus was able to utilize almost all the glucose and fructose within 48 h, whereas the maximum ethanol yield (0.48 g produced ethanol/g consumed sugars) was achieved by FSSF at 32 degrees C, 80% moisture, and particle size of https://www.selleckchem.com/products/ly3039478.html 20-80

mesh with 5 g/L fungal biomass concentration. Moreover, simultaneous saccharification and fermentation of the stalk glucan (10, 25, and 50 g/L) was performed at 32, 35, and 37 degrees C with different cellulase and beta-glucosidase enzymes loading for 48 h. In the best case, 85.6% of ethanol yield was achieved when 50g glucan/L was saccharified using 15 FPU cellulase and 30 IU beta-glucosidase per gram glucan and simultaneously fermented to ethanol at 37 degrees C for 48 h. The results indicated that the FSSF acted as a pretreatment stage and assisted the subsequent simultaneous saccharification

and fermentation process of the residual check details solid, resulted in up to 4.3 times improvement in the ethanol production yield. (C) 2013 Elsevier B.V. All rights reserved.”
“Aim:

To investigate human granulosa luteinized cells as a local source of atrial natriuretic peptide (ANP) and its relationship to cell viability, development of preovulatory follicles and fertilization rate of oocytes.

Material and Methods:

Indirect immunofluorescent technique, proANP kit, 4’6-Diamidino-2-phenylindole (DAPI)-DNA staining and Caspase-3 activity assay were used to examine

localization patterns, concentrations in selleck chemicals llc follicular fluids (FFl) and antiapoptotic role of ANP, respectively.

Results:

ANP is expressed on granulosa cells with membrane, submembrane and specific granular cytoplasmic localization. Significant differences in the mean concentrations of ANP in FFl and in the mean levels of apoptotic human granulosa luteinized cells (GLC) were found between women with high and low immunoreactive ANP expression (P < 0.05). Concentrations of ANP correlated inversely and significantly with the percentage of apoptotic GLC isolated from the same women (r = -0.2645; P < 0.05). Enhanced in vitro production of ANP by granulosa cells (after sodium nitroproside and 2Bu-cGMP treatment), as well as after treatment with human recombinant ANP was associated with significant suppression of Caspase-3 activity compared to control cells (P < 0.05). Concentrations of ANP in FFl correlated positively and significantly with the number of punctured follicles and oocytes retrieved (r = 0.44716, r = 0.57854; P < 0.05) and with the fertilization rate of oocytes in vitro (r = 0.59773; P < 0.05).

Conclusion:

Human granulosa luteinized cells are a local source of ANP in the preovulatory human follicle, which acts as a survival factor through cGMP signaling, and its levels in follicular fluids are positively associated with the number of punctured follicles, isolated oocytes and their fertilizability in vitro.

Study design. Clinical data, microscopical characteristics, and ki-67 immunoexpression

were comparatively analyzed on 2 intraoral sebaceous adenomas, 6 intraoral sebaceous hyperplasias, and 21 normal intraoral sebaceous glands.

Results. Clinically, sebaceous glands presented as multiple separated papules, sebaceous hyperplasias as a single enlarged papule, and sebaceous adenoma as a well-defined nodule. Microscopically, sebaceous adenoma presented DZNeP clinical trial an increased number of lobules, smaller lobules, and a greater number of germinative/squamous cells. Sebaceous hyperplasia also had an increased number of lobules and fewer number of germinative/squamous cells, as compared to normal oral sebaceous glands. Ki-67 expression was seen only in germinative cells and counts were higher in sebaceous adenomas followed by hyperplasias and normal glands.

Conclusions. Sebaceous hyperplasias and adenomas showed different clinical, microscopic, and proliferative characteristics, suggesting the usefulness of the studied criteria on diagnosis of these uncommon oral lesions. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: 100-104)”
“Objective. The magnification and distortion of images made from scanning and nonscanning CCD cephalometric systems was evaluated.

Study design. Acrylic box and dry human skull phantoms

were imaged using a conventional cephalostat, the nonscanning Kodak 8000C, the horizontally scanning GE/Instrumentarium OC100D, and the vertically scanning Sirona OrthophosDS. True linear and angular measurements of the phantoms Proteasome inhibitor find more were made using a coordinate measuring system and the

Hitachi MercuRay cone beam system. The accuracy of linear and angular measurements was assessed, as were magnification and distortion, where appropriate.

Results. Statistically significant differences between linear and angular measurements were found for almost all measurements for both phantoms. In general, the conventional cephalostat and Sirona OrthophosDS systems produced the greatest magnification and distortion while the GE/Instrumentarium OC 100D and Kodak 8000C systems, the least.

Conclusions. Measurement differences related to the beam geometries of these systems could not be predicted a priori. Unaccounted for, these differences could result in clinically significant consequences. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: 105-112)”
“We herein describe a molecular analysis based on the 3′ region of the glycoprotein C gene of 45 bovine herpesvirus (BoHV) isolates from Brazil (n = 41), Uruguay (n = 2) and Argentina (n = 2). Nucleotide (nt) sequencing and alignment of 333 nt revealed levels of similarity ranging from 99.1% to 100% among BoHV-1 sequences (n = 12); 96.2-100% among BoHV-5 sequences (n = 32); and 77.7-90.3% between BoHV-1 and BoHV-5 sequences.

(Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:e1-e6)”
“We have calculated the inelastic mean free path, stopping power, and energy-loss PF-04929113 straggling of swift electron, proton, and alpha-particle beams

in a broad incident energy range in four organic polymers: poly(methyl methacrylate) (PMMA), Kapton, polyacetylene (PA), and poly(2-vinylpyridine) (P2VP). These calculations have been done through a suitable description of their optical properties and its extension into the whole momentum and energy transfer excitation spectrum. For electrons, we take into account the exchange effect between the projectile and the target electrons, while the charge-state fractions have been considered for ions. Our results are compared with other models and with the available experimental data. An excellent agreement with experimental data is obtained in the case of proton and alpha-particle beams in Kapton and a reasonably good agreement has been achieved for electron beams in PMMA, Kapton, and PA. We have parameterized by means of simple analytical expressions our results for electron beams interacting with these four polymers, which can be easily implemented in Monte Carlo calculations. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3581120]“
“. Dendritic cells (DCs) are likely to

play a key role in the compromised T-cell function associated with hepatitis C Virus (HCV) infection. However, studies of DC function in HCV-infected patients to date have yielded conflicting findings check details possibly because of patient and virus heterogeneity. Here, we report the characterization of monocyte-derived DCs obtained from a homogenous cohort of women who were infected with HCV genotype 1b following exposure Epigenetic inhibitor concentration to contaminated anti-D immunoglobulin from a single donor source. Patients included in the study had not received anti-viral therapy

and all had mild liver disease. We show that phenotypically normal monocyte-derived dendritic cells (MDDCs) (CD11c+HLA-DR+CD1a+CD14lo) can be obtained from these patients. These cells respond to both Poly(I:C) and LPS, by up-regulating expression of CD86. They secrete high levels of IL-8 and CCL5 in response to LPS, an indication that the MyD88-dependent and MyD88-independent signalling pathways downstream of TLR4 ligation are functioning normally. However, these cells are poor stimulators of T-cell proliferation in allogeneic mixed lymphocyte reactions. Furthermore, patient MDDCs fail to secrete IFN-a in response to poly(I:C) or IFN-beta stimulation. Altered DC function may contribute to impaired cellular immune responses and chronicity of disease following HCV infection in this cohort.

METHODS: This prospective Sapanisertib in vitro randomized study was conducted at a university teaching medical center between June 2008 and December 2010. Pregnant women admitted for induction of labor with a live singleton gestation in cephalic presentation with intact membranes and a Bishop score of 6 or less were randomly assigned for cervical ripening by a single-balloon catheter or a double-balloon catheter. The primary outcome was the length of time from catheter insertion until

delivery. The secondary outcome was mode of delivery.

RESULTS: Of 368 eligible women screened during the study period, 293 were included in the final analysis; 145 were randomly assigned to receive a single-balloon catheter and 148 received a double-balloon catheter. Demographic and obstetric parameters were comparable between the two groups. Length of time from catheter insertion until delivery was 19.4 (+/- 6.0) and 19.1 (+/- 6.8) hours among the single-balloon and the double-balloon catheter groups, respectively (P=.80).

Length of time did not differ when primiparous women were analyzed separately. Incidence of cesarean delivery was 10.3% and 17.6% among the single-balloon and double-balloon catheter groups, respectively (P=.09). The incidence of either vacuum deliveries or www.selleckchem.com/products/AZD6244.html cesarean deliveries was significantly lower among the single-balloon group (14.4%) compared with the double-balloon catheter group (25.7%; odds ratio 0.49, 95% confidence interval 0.26-0.92; P=.02).

CONCLUSION: Both the single-balloon and double-balloon catheters are equally efficacious for inducing labor. The double-balloon catheter may be associated with more operative deliveries. BTK screening CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials. gov, NCT00690040. (Obstet Gynecol 2011;118:79-86) DOI: 10.1097/AOG.0b013e318220e4b7″
“Optoacoustic tomography has recently demonstrated powerful performance in small animal imaging and

initial clinical trials in terms of the high spatial resolution, versatile contrast, and dynamic imaging capabilities it can provide. Yet, the current optoacoustic image reconstruction methods are usually based on inaccurate forward modelling approaches or otherwise demand a high computational cost, which imposes certain practical limitations and hinders image quantification. Herein, we introduce a new method for accelerating optoacoustic reconstructions, based on angular image discretization of the forward model solution. The method is particularly suitable for accurate image reconstruction with arbitrary meshes and space-dependent resolution, while it can also readily account for small speed of sound variations without compromising the calculation speed. It is further anticipated that the new approach will greatly facilitate development of high performance 3-D optoacoustic reconstruction methods.

Outcome Measures. Treatment sequence, continuation, switching, and comedication.

Results. In total, 22,997 patients with a first NeuP in 2007 or 2008 were identified, out of which 2% also had epilepsy and 39% had a mood disorder. The remaining 13,749 patients were assumed to be treated for neuropathic pain, out of which 16% had a neuropathy diagnosis, 18% had a mixed pain diagnosis, and the remaining

66% had another DRCP. The most common first prescription was amitriptyline (40%) followed by pregabalin (22%) and gabapentin (19%). More than half had discontinued treatment after 3 months, and 60-70% at 6 months. Seven percent received another NeuP drug within 6 months of the discontinuation of their first NeuP treatment, 11% had another analgesic and 22% had a prescription indicating psychiatric comorbidity (selective serotonin reuptake inhibitors or benzodiazepine).

Conclusions. Protein Tyrosine Kinase inhibitor Treatment initiation of currently available drugs indicated for neuropathic pain less frequently lead to long-term treatment in clinical practice compared with clinical trial, and few try more than one drug. We suggest our findings to be indications of a need for better routines in diagnosing patients to ascertain optimal treatment and follow-up.”
“The antiferromagnetic state observed in Lu2Fe17 at elevated

temperatures is stabilized down to the ground state in (Lu0.8Ce0.2)(2)Fe-17 and Lu2Fe16.5Ru0.5. The Neel temperature T-N decreases from 274 K in Lu2Fe17 to 247 and 208 K in (Lu0.8Ce0.2 MAPK inhibitor )(2)Fe-17 and Lu2Fe16.5Ru0.5, respectively. Both compounds exhibit the easy-plane type of magnetic BAY 80-6946 concentration anisotropy and a metamagnetic transition at fields below 1 T. External pressure pushes the transition toward a higher field and reduces the magnetization as well as T-N to 234 and 185 K for (Lu0.8Ce0.2)(2)Fe-17 and Lu2Fe16.5Ru0.5, respectively, under pressure 0.8 GPa. The pressure and the substitution effects can be understood in terms of exchange interaction varying strongly with changes in the lattice parameter c for (Lu0.8Ce0.2)(2)Fe-17, while for Lu2Fe16.5Ru0.5, the change in magnetic structure occurs due to the

weakening of the positive exchange interaction as a result of the reduction in the Fe magnetic moments at 12 k sites. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3075584]“
“Disodium-fosfomycin pharmacokinetics has been studied in different species after oral, intravenous, intramuscular and subcutaneous administration. At present there are neither documented clinical experiences of the use of fosfomycin in pigs nor any published studies in weaning piglets, although it is a period of high incidence of infectious diseases. The pharmacokinetics and the bioavailability of sodium fosfomycin were studied in post weaning piglets after intravenous and intramuscular administration of 15 mg/kg of body weight. Plasma concentrations were measured by a high-performance liquid ms/ms.

Conclusion: Over five decades of methodological development have provided a rich array of HRQL instruments. A plethora of technologies facilitate the collection, transmission, and storing

of information. What is needed is training to assist patients and providers in the meaning and use of such information and the will to use it to improve performance, accountability, and patient care. Administrative support is also necessary. (c) 2013 Elsevier Inc. All rights reserved.”
“Aims The aim of most pelvic floor disorders (PFD) research is to obtain an unbiased effect estimate and to make causal inferences. New developments in epidemiologic selleckchem research, including the use of causal directed acyclic graphs (DAGs), have shown that traditional analytical strategies for research can be inadequate, leading to unintended consequences such as introducing additional bias. Although DAGs have been proven to be useful in other medical fields, their use has been limited in PFD research. The aim of this paper is to introduce DAGs and then demonstrate their application in PFD research. This paper will also illustrate how relying purely on statistical

techniques can lead to pitfalls in reducing bias in research studies. Methods/Results: DAGs are a graphical epidemiologic CX-6258 mw tool that provide a method to select for potential confounders and minimize bias in the design and analysis of research studies. We start by providing an introduction to DAGs. We then describe six scenarios in PFD research in which DAGs can be helpful: (1) identifying appropriate confounding variables for adjustment; (2) identifying potential over-adjustment when conditioning Selleckchem Crenigacestat on a mediator; (3) identifying unintended confounding due to inappropriate adjustment; (4) identifying unintended selection bias due to inappropriate adjustment; (5) planning analyses in cross-sectional studies; and (6) using DAGs as a framework to help

plan data collection and analyses in PFD research. Conclusions: We demonstrate how the application of DAGs as an aid to PFD research can help to decrease bias and discuss the insights and implications for study design and analytical approaches. Neurourol. Urodynam. 31:115-120, 2012. (C) 2011 Wiley Periodicals, Inc.”
“Background: Ovarian cancer (OC) is the sixth most common cancer in women. Currently, carboplatin/paclitaxel +/- bevacizumab is the cornerstone of front-line treatment. Conversely, the therapeutic options for recurrent or progressive disease are not well defined. For platinum-sensitive patients the best therapeutic approach is still a re-challenge with a platinum-based regimen. Pegylated liposomal doxorubicin (PLD), is considered one of the most active therapeutic options for recurrent or progressive OC. In this retrospective mono-institutional analysis, we evaluated the impact of PLD on the outcome of OC patients.