“KETEYIAN, S. J., D. KITZMAN, F. ZANNAD, J. LANDZBERG, J. M. ARNOLD, P. BRUBAKER, C. A. BRAWNER, D. BENSIMHON, A. S. HELLKAMP, and G. EWALD. Predicting Maximal HR in Heart Failure Patients on beta-Blockade Therapy. Med. Sci. Sports Exerc., Vol. 44, No. 3, pp. 371-376, 2012. Purpose: Standards for estimating maximal HR are important when interpreting the adequacy of physiologic stress during exercise testing, assessing chronotropic response, and prescribing an
exercise training regimen. The equation 220 – age is used to estimate maximum HR; however, it overestimates measured maximal HR in patients taking beta-adrenergic blockade (beta B) therapy. This study developed and validated a learn more practical equation to predict maximal HR in patients with heart AZD6244 molecular weight failure (HF) taking beta B therapy. Methods: Data from symptom-limited exercise tests completed on patients with systolic HF participating in the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training trial and taking a beta B agent were used to develop a simplified equation, which was validated using bootstrapping. Results: The simplified
derived equation was 119 + 0.5 (resting HR) – 0.5 (age) – (0, if test was completed using a treadmill; 5, if using a stationary bike). The R-2 and SEE were 0.28 and 18 beats.min (1), respectively. Validation of this equation yielded a mean R-2 and SEE of 0.28 and 18 beats.min(-1), respectively. For the equation 220 – age, the R-2 was -2.93, and the SEE was 43 beats.min(-1). Conclusions: We report a valid and simple population-specific equation for estimating peak HR in patients with HF taking
beta B therapy. This equation should be helpful when evaluating chronotropic response or assessing if a maximum effort was provided during exercise testing. We caution, however, that the magnitude of the variation (SEE Sapanisertib in vitro = 18 beats.min(-1)) associated with this prediction equation may make it impractical when prescribing exercise intensity.”
“The rates of biodegradation of endosulfan by P. aeruginosa were determined with different initial endosulfan concentrations (10, 50, 100, 150, 200 and 250 mg l(-1)) and different growth linked kinetic models were fitted at these concentrations. At 10 mg endosulfan l(-1), Monod no growth model was well fitted. Monod with growth model described the biodegradation pattern at an initial concentration of 50, 100 and 150 mg endosulfan l(-1). Significant increases of P. aeruginosa MN2B14 density in broth culture during incubation further support this result. Conversely, zero order kinetic model was well fitted into the biodegradation data if initial endosulfan concentration was a parts per thousand yen200 mg endosulfan l(-1). The kinetics of endosulfan biodegradation by P. aeruginosa MN2B14 in liquid broth was highly dependent upon its initial concentration.