Results. Our results showed that even though both equations provided a good correlation (p < 0.001) with GFR evaluated by the nuclear medicine method, they underestimated the GFR value in comparison to nuclear medicine methods. Our study also found that CKD-EPI was superior to MDRD. Conclusion. Using purely creatinine-based GFR estimates can lead to complications in clinical practice, especially when correct GFR values are mandatory, like when calculating adequate chemotherapy dosage, and should be used with caution.
When the more accurate nuclear medicine methods are unavailable due to cost or accessibility issues, our study showed that the new CKD-EPI appears to reflect GFR results more accurately than MDRD, and thus should be the method of choice for estimating GFR.”
“We sought to measure serum salusin-alpha selleck products levels in patients with coronary artery disease (CAD) and to assess their correlation with the severity of the disease.
We enrolled 172 patients with CAD and 91 controls. We assessed the angiographic severity of CAD by coronary atherosclerosis index (CAI) and detected serum salusin-alpha levels by enzyme-linked immunosorbent assay (ELISA). We demonstrated that CAD patients had significantly lower serum salusin-alpha levels compared to controls. Moreover, serum salusin-alpha levels were independently and negatively correlated with the presence and severity of CAD. These findings indicated that salusin-alpha might serve Barasertib datasheet as a potential biomarker for predicting the development and progression of CAD.”
“We aimed to detect neopterin concentrations in serum and synovial
fluid (SF) of knee osteoarthritis (OA) patients and to clarify their relationship with clinical severity of the disease. We cross-sectionally enrolled 176 knee OA patients and 63 age- and sex-matched controls. We measured neopterin concentrations by enzyme-linked immunosorbent assay (ELISA) and investigated the correlation between serum/SF neopterin concentrations and Kellgren-Lawrence selleck chemicals llc (KL) grades as well as Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores in OA patients. Our results demonstrated that increased SF neopterin concentrations were independently correlated with greater symptomatic and radiographic severity in OA patients. These results suggested a crucial role of neopterin activation in the development and progression of knee OA. Assessment of neopterin levels in SF is a potential biomarker to evaluate disease severity in OA patients.”
“Background. Observational studies from low-income countries have shown that the vaccination against diphtheria, tetanus and pertussis (DTP) is associated with excess female mortality due to infectious diseases. Methods.