“Ethnopharmacological relevance: Jujuboside A (JuA) is a m


“Ethnopharmacological relevance: Jujuboside A (JuA) is a main active ingredient of semen ziziphi spinosae, which can significantly reduce spontaneous activity in mammals, increase the speed of falling asleep, prolong the URMC-099 cost sleeping time as well as improve the sleeping efficiency. In this study, the mechanism and the pathway of the sedative and hypnotic effect of JuA were investigated. Materials and methods: After being treated with JuA (in vitro), the rat’s small intestine tissues cultures were used to stimulate the brain tissues. Then 27 cytokine levels were detected in the two kinds of tissue culture via liquid protein chip technology;

In addition, the cultured hippocampal neurons of rat were treated with JuA, and gamma-aminobutyric acid (GABA) receptor subunits (GABA(A)alpha(1), GABA(A)alpha(5), GABA(A)beta(1) and GABA(B)R(1)) mTOR inhibitor mRNAs were evaluated by Real-time PCR. Results: The levels of IL-1 alpha, MIP-1 alpha, IL-1 beta and IL-2 were reduced significantly after 3 h

of treating the small intestine tissues with JuA (200 mu l/ml), and the concentration change rates, in order, were -593%, -3.59%, -50.1% and -49.4%; these cytokines were transmitted to brain tissues 2 h later, which could lead to significant levels of reduction of IL-1 alpha, IFN-gamma, IP-10 and TNF-alpha; the concentration change rates were -62.4%, -25.7%, -552% and -38.5%, respectively. Further, the intercellular communication network diagram was mapped out, which could suggest the mechanism and the pathway of the sedative and hypnotic effect of JuA. The results also indicated that JuA (50 mu l/ml) increased significantly GABA(A)alpha(1), receptor mRNAs and reduced

GABA(B)R(1), mRNAs in hippocampal neurons after 24 h of stimulation; however, all the mRNA transcription levels of GABA(A)alpha(1),GABA(A)alpha(5), GABA(A)beta(1) and GABA(B)R(1) receptors increased significantly after 48 h. Conclusion: JuA performed its specific sedative and hypnotic effect through check details not only adjusting GABA receptors subunit mRNAs expression, but also down-regulating the secretion of relevant inflammation cytokines on the intestinal mucosal system to affect the intercellular cytokine network between nerve cells in the brain. This mechanism is similar to that of melatonin. (C) 2014 Elsevier Ireland Ltd. All rights reserved.”
“IL-17-producing T cells (Th17) have been found to play important roles in several liver diseases, but few studies have evaluated the function of such cells in hepatitis B (HBV)-related diseases, especially in hepatic fibrosis. In this study, we examined the expression of IL-17 in patients with different chronic HBV-related diseases, and assessed the association between IL-17 expression and the degree of fibrosis. The method of immunohistochemistry was used to evaluate the localization of intrahepatic IL-17.

The MFC generated the maximum power when the contact area between

The MFC generated the maximum power when the contact area between the anode and bacteria was the largest. (C) 2012 The Japan Society of Applied Physics”
“Fe-Cr alloys with different Cr contents were prepared by an arc melting technique.

The alloys were isochronally aged in the range from 400 degrees C to 900 degrees C with 50 degrees C steps with a holding time of 100 hours. The ageing produced embrittlement in the alloys due to either the formation of a Cr-rich alpha’ phase or a sigma phase at high temperatures. Magnetic Hysteresis Loop (MHL) and Micro-Vickers hardness were measured at each step to correlate the magnetic and mechanical properties. Coercivity and hardness of the alloys were increased and remanence decreased up to 500-550 degrees C learn more due to formation of a Cr-rich alpha’ phase. Beyond

500-550 degrees C range, the coercivity and hardness decreased and remanence increased due to the coarsening or dissolution of the Cr-rich alpha’ phase. In the Fe-48% Cr alloy, formation of the sigma phase at 700 degrees C reduced the maximum induction of the alloy significantly.”
“Objectives Intention tremor becomes evident only when patients intend to move their body and Blebbistatin cost is characterized by dysmetria. We have developed an on-demand control system that triggers the switching on/off of deep brain stimulation (DBS) instantly for the control of intention tremor. Material and Methods We used surface electrodes for the recording of electromyographic (EMG) activity, and the power of EMG activity was analyzed instantly employing the fast Fourier transform. The on-demand control system switched on DBS when only the power of tremor frequency exceeded the on-trigger threshold, and the system switched off DBS when the total power of EMG activity decreased below the off-trigger threshold. Results The on-demand control system triggered the switching on/off of DBS accurately, and controlled intention tremor completely. Our on-demand control system GS-1101 manufacturer is small and portable,

and suitable for clinical use. Conclusions The on-demand control system for DBS is useful for controlling intention tremor and may decrease the incidence of tolerance to DBS and may be a powerful tool for various applications of neuromodulation therapy.”
“Males from gift-giving species attempt to obtain food to offer to females. Therefore, food access may affect both their body condition and their reproductive success. In some species, males reduce the costs associated with giving gifts by reusing gifts, or by offering inedible items. Males from the spider Paratrechalea ornata (Trechaleidae) offer fresh prey or ‘genuine gifts’ to females, but also offer prey leftovers or ‘worthless gifts’. We examined gift weight and content, and their relation to male condition in the field. We also investigated how gift content, male condition and female reproductive status (virgin/mated) affect male mating success.

The clinical background, tumor recurrence rate, overall survival

The clinical background, tumor recurrence rate, overall survival rate, and prognostic values of the patients were assessed.\n\nResults: The size of CC-HCCs was larger than that of HCV-HCCs (P = 0.01). The respective tumor recurrence Veliparib rates at 1, 3, and

5 years were 11%, 32%, and 46% in the CC-HCC, and 21%, 59%, and 81% in the HCV-HCC. The respective overall survival rates at 1, 3, and 5 years were 94%, 85%, and 80% in the CC-HCC, and 98%, 81%, and 61% in the HCV-HCC. CC-HCC patients had a lower tumor recurrence rate and a higher survival rate compared to the HCV-HCC patients (P = 0.001 and P = 0.02, respectively). Via multivariate analysis, significant factors for high recurrence rate were number of HCCs (P = 0.02) and serum alpha fetoprotein levels (P = 0.03) in CC-HCC, whereas multiple tumors (P < 0.001), large tumor Selleck AZD9291 size (P = 0.01), and high alanine aminotransferase (P = 0.04) in HCV-HCC. The factor for survival was albumin in both groups.\n\nConclusion: The size of CC-HCC was larger than that of HCV-HCC even in patients who received curative treatment; however, the risk for recurrence and the mortality of the patients with CC-HCC was lower than those with HCV-HCC.”
“Head and neck squamous cell carcinoma (HNSCC) is

a common, morbid, and frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs. The majority exhibited a mutational profile consistent with tobacco exposure; human papillomavirus was detectable by sequencing DNA from infected tumors. In addition to identifying previously known HNSCC genes (TP53, CDKN2A, PTEN, PIK3CA, and HRAS), our analysis revealed many genes not previously implicated in this malignancy. At least 30% of cases harbored mutations in genes that regulate squamous differentiation (for example, NOTCH1, IRF6,

and TP63), implicating its dysregulation as a major driver of HNSCC carcinogenesis. More generally, the results indicate the ability of large-scale sequencing selleck inhibitor to reveal fundamental tumorigenic mechanisms.”
“Background: Extended oncologic outcomes after minimally invasive cystectomy have not been previously reported.\n\nObjective: To report outcomes of robot-assisted radical cystectomy (RARC) and laparoscopic radical cystectomy (LRC) for bladder cancer (BCa) at up to 12-yr follow-up.\n\nDesign, setting, and participants: All 121 patients undergoing RARC or LRC for BCa between December 1999 and September 2008 at a tertiary referral center were retrospectively evaluated from a prospectively maintained database.\n\nIntervention: RARC or LRC.\n\nOutcome measurements and statistical analysis: Primary end points were overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) calculated using Kaplan-Meier curves. Secondary end points were survival analysis by number of lymph nodes (LNs) and type of procedure. Surgical outcomes, including complications, were analyzed.


“PURPOSE: To analyze the expression of hypoxia inducible f


“PURPOSE: To analyze the expression of hypoxia inducible factor 1 alpha (HIF1A) and its correlation with clinical outcome in men with localized prostate cancer (PC) treated with dose escalation radiotherapy (RT) and androgen deprivation (AD). METHODS: Between 1996 and 2004, 129 PC patients who had diagnostic

biopsies pre-treatment and 24-36 months following RT were enrolled in this study. Median follow-up was 129 months. Suitable archival diagnostic tissue was obtained from 86 patients. Correlation analysis was done to assess association between HIF1A expression and clinical outcome. RESULTS: HIF1A expression was observed in 25/86 (29%) of diagnostic biopsies, and in 5/14 (36%) of post-RT biopsies. No significant association was noted between HIF1A expression and clinical and treatment

S63845 parameters. We also failed to show a significant correlation between HIF1A overexpression and outcome. A borderline significant relationship was observed between expression of HIF1A and overall survival (OS) (HR 0.03, p = 0.08). CONCLUSION: To our knowledge this is the first study assessing the pattern of change of HIF1A staining in biopsies of patients prior and following treatment. While we did not find significant variations in the expression of HIF1A following radio-hormone therapy, a high HIF1A expression was unexpectedly associated with a borderline improved OS.”
“Purpose: The purpose of this report was to describe a case of choroidal detachment after an uneventful intravitreal injection using a 30-gauge needle.\n\nMethods: An 88-year-old patient with ATM inhibitor SRT2104 acute onset of neovascular age-related macular degeneration developed a choroidal detachment after an uneventful intravitreal injection in the infero-temporal aspect of the fundus.\n\nResults: The patient described no symptoms related to the chorioretinal detachment. Additional intravitreal injections were required to treat an active subfoveal

choroidal neovascularization. These injections were placed at the contralateral side in the supero-nasal quadrant. She was closely watched on a 2-week follow-up schedule. The choroidal detachment remained asymptomatic for the patient and resolved spontaneously, and the best corrected visual acuity improved from 0.2 to 0.63 during a 6-month follow-up. A mild hyperpigmentation remained at this location.\n\nConclusion: Asymptomatic choroidal detachments may occur after intravitreal injection. Although treatment was not needed, additional injections should be avoided in the same quadrant until the detachment has resolved.”
“Background and aim: Subtle changes in hypothalamic-pituitary-adrenal (HPA) axis of subjects with non-functioning adrenal adenoma may be associated with endothelial alterations. We sought to investigate endothelial function, visceral adiposity and osteoprotegerin (OPG) and interleukin-18 (IL-18) levels in subjects with non-functioning adrenal adenomas.


“The

relationship between mutated proteins and the


“The

relationship between mutated proteins and the cancer stem-cell population is unclear. Glioblastoma tumors frequently express EGFRvIII, an EGF receptor (EGFR) variant that arises via gene rearrangement and amplification. However, expression of EGFRvIII is restricted despite the prevalence of the alteration. Here, we show that EGFRvIII is highly coexpressed with CD133 and that EGFRvIII(+)/CD133(+) defines the population of cancer stem cells (CSC) with the highest degree of self-renewal and tumor-initiating ability. EGFRvIII+ cells are associated with other stem/progenitor markers, whereas markers of differentiation are found Selleck Autophagy inhibitor in EGFRvIII(-) cells. EGFRvIII expression is lost in standard cell culture, but its expression is maintained in tumor sphere culture, and cultured find more cells also retain the EGFRvIII(+)/CD133(+) coexpression, self-renewal, and tumor initiating abilities. Elimination

of the EGFRvIII(+)/CD133(+) population using a bispecific antibody reduced tumorigenicity of implanted tumor cells better than any reagent directed against a single epitope. This work demonstrates that a mutated oncogene can have CSC-specific expression and be used to specifically target this population. (C)2013 AACR.”
“Myeloproliferative neoplasms

(MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are predisposed to leukemic transformation. Hematopoietic stem cells are the suspected disease-initiating cells, and these cells Wnt pathway must acquire a clonal advantage relative to nonmutant hematopoietic stem cells to perpetuate disease. In 2005, several groups identified a single gain-of-function point mutation in JAK2 that associated with the majority of MPNs, and subsequent studies have led to a comprehensive understanding of the mutational landscape in MPNs. However, confusion still exists as to how a single genetic aberration can be associated with multiple distinct disease entities. Many explanations have been proposed, including JAK2V617F homozygosity, individual patient heterogeneity, and the differential regulation of downstream JAK2 signaling pathways. Several groups have made knock-in mouse models expressing JAK2V617F and have observed divergent phenotypes, each recapitulating some aspects of disease. Intriguingly, most of these models do not observe a strong hematopoietic stem cell self-renewal advantage compared with wild-type littermate controls, raising the question of how a clonal advantage is established in patients with MPNs.

Benzoic acid derivatives showed low concentration in the plasma (

Benzoic acid derivatives showed low concentration in the plasma (<30 nM) and in the diets. The exception was p-hydroxybenzoic acid, with a plasma concentration (4 +/- 0.4 mu M), much higher than the other plant phenolic acids, likely because it is an intermediate in the phenolic acid metabolism. It was concluded

that plant phenolic acids undergo extensive interconversion in the colon and that their absorption profiles reflected their low bioavailability in the plant LGX818 in vitro matrix.”
“Microscopic vascular invasion is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. To predict microscopic portal venous invasion, the following two questions were examined retrospectively: Is it possible to detect microvascular invasion preoperatively? What are the characteristics of a group of early HCC recurrences even with no microvascular invasion?\n\nStudy 1 included 229 patients with HCC who underwent curative liver resection between 1991 and 2008; 127 had HCC without microscopic portal venous invasion, and 52 had HCC with microscopic portal venous invasion (MPVI).

These two distinct groups were analyzed with regard to various clinicopathologic factors. Subsequently, we specifically investigated if HCCs < 5 cm with vascular invasion (n = 32) have some characteristics that would allow detection of latent microvascular invasion. Study 2 included 127 HCC patients without MVPI; 42 had a recurrence within 2 years, and 85 patients were recurrence-free for at AZD0530 in vivo least 2 years. These two distinct groups were analyzed with regard to various clinicopathologic factors.\n\nHCC diameter of > 5 cm, the macroscopic appearance of HCC, and high levels of preoperative

des-gamma-carboxyprothrombin are significant prognostic factors in identifying microvascular invasion of HCC. The strongest predictor of early recurrence (within 2 years) was the serum alpha-fetoprotein level in patients without clear microvascular invasion.\n\nTumor size, macroscopic appearance, and high tumor marker levels are important elements in identifying the group of patients with a low HCC recurrence rate C59 Wnt after curative liver resection.”
“Objective To evaluate the safety and efficacy of an adjustable artificial urethral sphincter (AUS) in a population of dogs with acquired or congenital urinary incontinence. Study Design Case series. Animals Dogs (n = 27) with naturally occurring urinary incontinence. Methods Medical records (January 2009July 2011) of dogs that had AUS implantation for treatment of urinary incontinence were reviewed and owners were interviewed by telephone to assess outcome. Continence was scored using a previously established analogue scale, with 1 representing constant leakage and 10 representing complete continence. Results Twenty-four female and 3 male dogs had AUS implantation.

We found that the offspring of mothers with a serological pattern

We found that the offspring of mothers with a serological pattern consistent with Toxoplasma type I infection were at significantly increased risk for the development of psychoses as compared with the matched unaffected control mothers (odds ratio = 1.94, 95% confidence interval = 1.08-3.46; p = 0.03). The risk was particularly elevated for affective psychoses (OR = 5.24, 95% CI = 1.67-16 5; p = 0 005). In contrast, we did not find an association between maternal antibodies to other genotypes and risk of psychoses in the offspring These findings suggest in influence of the parasite genotype on increased risk of

psychosis and provide further support for a substantive role of Toxoplasma in the etiology of psychosis. (C) 2009 Elsevier Masson SAS All rights reserved”
“AIM: To investigate the diagnostic significance of foot plantar pressure find more distribution abnormalities in patients with diabetic

selleck chemical peripheral neuropathy (DPN).\n\nPATIENTS AND METHODS: A total of 107 patients were divided into normal control (28 participants, 56 feet), non-DPN (56 patients, 112 feet), and DPN groups (23 patients, 46 feet). Foot plantar pressure was measured while patients walked at a constant speed over a flat floor using F-Scan pressure insoles. Recordings of six middle strides were averaged to evaluate the characteristics of foot plantar pressure distribution.\n\nRESULTS: Compared with the normal group, the time of contact (TOC) was longer in non-DPN (p < 0.05) and DPN groups (p < 0.01). The foot to floor force-time integral (FTI) was increased in DPN group (p < 0.01). The forefoot plantar force ratio increased in non-DPN and DPN patients (p < 0.05). Moreover, in DPN patients, the ratio of lateral foot plantar force increased (p < 0.05). Selleck Ulixertinib The examination of the correlations between biomechanical parameters of the foot

plantar and electrophysiological parameters of the lower limbs showed foot plantar biomechanical abnormalities correlated with abnormal sensory conduction of the sural nerve and motor conduction of the common peroneal nerve. Receiver operating characteristic (ROC) analysis showed the area under FTI curve was 0.714 (p < 0.001).\n\nCONCLUSIONS: The plantar pressure was shifted towards the side of the forefoot in DPN patients. The foot plantar biomechanical changes were closely correlated with lower limb paresthesia and contraction abnormalities of lower-limb extensor muscles. Foot plantar pressure measurement might be used as a screening tool for early diagnosis of DPN.”
“Background and Aims Various markers are used to monitor disease activity in paediatric Crohn’s disease (CD).

Three commonly encountered species, Heterolepidoderma ocellatum,

Three commonly encountered species, Heterolepidoderma ocellatum, Lepidochaetus zelinkai, and Lepidodermella squamata, are investigated for cryptic speciation. Most of the material is based on Swedish ACY-738 specimens but closely related species from other parts of the world are also included. Taxonomic revisions are supported by phylogenies based on 18S rRNA, 28S rRNA, and COI mtDNA of freshwater Chaetonotidae from several genera and inferred from Bayesian and maximum likelihood approaches. Heterolepidoderma ocellatum f. sphagnophilum is raised to species level, under the name H. acidophilum n. sp. Moreover, genetic data based on COI indicate large variation between two morphologically very similar

groups of Lepidodermella squamata. The extent of cryptic speciation in L. zelinkai appears low. Based on the phylogenetic hypothesis presented in this article, the P005091 molecular weight new species, Lepidodermella intermedia n. sp., from northern Sweden is also described. The phylogenetic hypothesis generated shows that Chaetonotidae

is a non-monophyletic group.”
“The aim of this study was to examine the relationships among physical self-perception, body image and motor performance in Italian middle school students. Two hundred and sixty children were categorized into normal-weight (n=103), overweight (n=86) or obese (n=71) groups. Perceived coordination, body fat and sports competence were assessed using the Physical Self-Description Questionnaire, while body image was measured using Collins’ Child Figure Drawings. Individuals’ perceptions of strength, speed and agility were assessed using the Perceived Physical Ability Scale. Tests involving the standing Mdm2 inhibitor long jump, 2 kg medicine-ball throw, 10 x 5 m shuttle-run and 20 and 30 m sprints were

also administered. Girls, when compared with boys, and overweight and obese participants, when compared with normal-weight peers, reported lower perceived and actual physical competence, higher perceived body fat and greater body dissatisfaction. Body dissatisfaction mediated all the associations between body mass index (BMI) and the different aspects of physical self-perception in boys, but not in girls. The same pattern of results was found for physical self-perception as a mediator of the relationship between BMI and body dissatisfaction. In conclusion, obesity proved to have adverse effects on both motor performance and physical self-perception.”
“PFEIFFER, B., T. STELLINGWERFF, E. ZALTAS, and A. E. JEUKENDRUP. CHO Oxidation from a CHO Gel Compared with a Drink during Exercise. Med. Sci. Sports Exerc., Vol. 42, No. 11, pp. 2038-2045, 2010. Recently, it has been shown that ingestion of solutions with glucose (GLU) and fructose (FRC) leads to 20%-50% higher CHO oxidation rates compared with GLU alone. Although most laboratory studies used solutions to deliver CHO, in practice, athletes often ingest CHO in the form of gels (semisolid).

However, there were methodological limitations as majority of the

However, there were methodological limitations as majority of the papers were case series, which decreased the quality of the

evidence Ion Channel Ligand Library available. (C) 2012 Elsevier B.V. All rights reserved.”
“The introduction of anti-angiogenic drugs especially tyrosine kinase inhibitors (TKIs) was a breakthrough in the treatment of renal cell carcinoma (RCC). Although TKIs have significantly improved outcome in patients with metastatic disease, the majority still develop resistance overtime. Because different combinations and sequences of TKIs are tested in clinical trials, resistance patterns and mechanisms underlying this phenomenon should be thoroughly investigated. From a clinical point of view, resistance occurs either as a primary phenomenon (intrinsic) or as a secondary phenomenon

related to various escape/evasive mechanisms that the tumor develops in response to vascular endothelial growth factor (VEGF) inhibition. Intrinsic resistance is less common, and related to the primary redundancy of available angiogenic signals from the tumor, learn more causing unresponsiveness to VEGF-targeted therapies. Acquired resistance in tumors is associated with activation of an angiogenic switch which leads to either upregulation of the existing VEGF pathway or recruitment of alternative factors responsible for tumor revascularization. Multiple mechanisms can be involved in different tumor settings that contribute both to evasive and intrinsic resistance, and current endeavor aims to identify these processes and assess their importance in clinical settings and design of pharmacological strategies that lead to enduring anti-angiogenic therapies. (C)

2013 Published by Elsevier B.V.”
“MicroRNAs (miRNAs) are small non-coding RNA molecules capable of regulating multiple target genes through repression of mRNA stability or translation. miRNAs regulate a wide variety of developmental and pathological processes, and many have oncogenic or tumor suppressor activity. Carcinoma cells can undergo changes resembling a partial or transient epithelial-mesenchymal transition (EMT) as part of the metastatic cascade. Numerous miRNAs regulate EMT by targeting genes that control epithelial buy AZD9291 or mesenchymal characteristics. The involvement of miRNAs in feedback loops with EMT-regulating transcription factors reveals a critical role in governing epithelial plasticity. In this review we summarize miRNAs involved in carcinoma cell plasticity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Purpose: Brachytherapy after lumpectomy is an increasingly popular breast cancer treatment, but data concerning its effectiveness are conflicting. Recently proposed “suitability” criteria guiding patient selection for brachytherapy have never been empirically validated.

2009; 28(6): 1814-25]”
“Laser tweezers Raman spectroscopy (L

2009; 28(6): 1814-25]”
“Laser tweezers Raman spectroscopy (LTRS) was used to acquire the Raman spectra of leukemic T lymphocytes exposed to the chemotherapy drug doxorubicin at different time points over 72 hours. Changes observed in the Raman spectra were dependent on drug exposure time and concentration. The sequence of spectral changes includes an intensity increase in lipid Raman peaks, followed by an intensity increase in DNA Raman peaks, and finally changes in DNA and protein (phenylalanine)

Raman vibrations. These Raman signatures are consistent with vesicle formation, cell membrane blebbing, chromatin condensation, and the cytoplasm of dead cells during the different stages of drug-induced apoptosis. These results suggest the potential of LTRS as a real-time single cell tool for monitoring apoptosis, evaluating the efficacy of chemotherapeutic treatments, or pharmaceutical testing. (C)2010 Optical Society of America”
“In this study TPX-0005 soil samples were taken from the O/A and B horizons of undisturbed forest, active pasture, and 8- to 12-year-old teak and mixed native plantations. Samples were analyzed for K, Ca, HSP inhibitor drugs Mg, soil organic carbon, pH, exchangeable acidity, bulk density, and compared with a fertility equation. Bulk density was significantly lower in the undisturbed forest than other land uses, suggesting that after approximately

10 years of growth neither plantation lowered bulk density significantly from that of the active pasture, Teak plantations selleck kinase inhibitor had significantly higher Mg and

K (B horizon) and Ca (O/A horizon) concentrations than the undisturbed forest. This trend suggests that exchangeable base concentrations increase when land use changes from undisturbed forest to pasture, then pasture to plantation, with the most pronounced effect of this in teak plantations exhibiting more high fertility plots than other land uses. Soil organic carbon concentration was similar for all land uses except for a significantly lower concentration in teak plantations than in active pasture (O/A horizons). These results suggest that teak plantations may be advantageous for increasing soil fertility but, with respect to restoration of undisturbed forest conditions, present significant deviations in soil chemistry. Options for improved plantations soil management are discussed. Published by Elsevier B.V.”
“Xeroderma pigmentosum (XP) type C is a rare autosomal recessive disorder that occurs because of inactivation of the xeroderma pigmentosum group C (XPC) protein, which is an important DNA damage recognition protein involved in DNA nucleotide excision repair (NER). This defect, which prevents removal of a wide array of direct and indirect DNA lesions, is associated with a decrease in catalase activity. As a novel photoprotective approach, lentivirus-mediated catalase overexpression in XPC human keratinocytes results in a marked decrease in sunburn cell formation, caspase-3 activation, and p53 accumulation following UVB irradiation.