Patient and disease specific characteristics including severity of chronic liver disease (Child-Pugh class), bleeding severity (Rockall & Glasgow-Blatchford scores; need for transfusion) and outcomes (mortality) were examined in relation to TTE. Results: Of

1766 patients referred, 79 patients with variceal bleed were included in the analysis, after excluding those with 1) endoscopy elsewhere prior to admission (n = 2) 2) bleeding during admission (n = 11) & 3) incomplete or unreliable data (n = 7). Mortality was similar in patients who received endoscopy within 15 hours (8/62) compared to those that did not (1/17) (p = 0.675). Median TTE for patients who died was significantly shorter than for survivors (2.1 vs. 8.23 hours, p = 0.04). There was a moderate inverse correlation between TTE and the full Rockall score (rs = -0.519 p < 0.001), and a weaker inverse correlation Alectinib in vivo with the pre-endoscopy Rockall Score (rs = -0.39, p < 0.001) and Glasgow Blatchford

score (rs = -0.371, p = 0.011, n = 46). When adjusted for age, gender, presentation symptoms of either haematemesis and/or melaena, blood transfusion, pre-endoscopy Rockall score and TTE, mortality was significantly increased only in patients with Child Pugh Class C (OR 12.3, 95% CI 1.21–125.2). Conclusion: Time to endoscopy does not affect mortality in patients with variceal bleeding. However, it is influenced by patient’s condition with Edoxaban patients with more severe disease or bleeding receiving

endoscopy sooner. When adjusted for other factors, Child Pugh Class C was the main risk factor for mortality. Key Word(s): 1. varices; 2. quality; BGJ398 purchase 3. endoscopy; Presenting Author: ROMAN PLAKHOV Additional Authors: SERGEY SHAPOVALYANZ, EVGENY FEDOROV, LUDMILA MICHALEVA, ZALINA GALKOVA, EKATERINA IVANOVA, ANDREY SERGEENKO, DENIS SELESNEV, EVGENYA POLUCHINA Corresponding Author: ROMAN PLAKHOV Affiliations: Moscow University Hospital 31 Objective: Assessment of currently available methods of diagnostics and treatment of patients with bleeding gastrointestinal subepithelial tumours (SET). Methods: From 01.01.1999 till 01.01.2013 243 patients with SET have been treated; the bleeding was revealed in 64 (26,3%) cases. Mean age was 57,2 ± 7,2 years, range from 16 to 89 years; male – 31 (48,4%), female – 33 (51,6%). Preliminary diagnosis was determined by urgent EGD in 48 patients; enteroscopy in 15, colonoscopy in 1; EUS have been used in 43 patients, X-ray in 19, CT-scan in 19, mesentericography in 2. Endoscopic interventions were performed with videogastroscopes EVIS GIF-1T140R, GIF-2T160, GIF-H180, videoenteroscope SIF-Q180, videocolonoscope CF-Q160ZL and various endoscopic instruments; EUS was performed with echo-endoscopes GF-UM160, GF-UM20 and EUS-centers EU-M20, EU-M60 (all – Olympus, Japan). Electrosurgical unit ICC200+APC300 (ERBE, Germany) was used to remove SET.