(C) 2012 Elsevier Editora Ltda. All rights reserved.”
“Background: Right ventricular (RV) apical pacing may result in ventricular dyssynchrony, which is associated with functional and morphological changes in the
left ventricle (LV) Our aim is to assess contraction and hypertrophy-related protein expression changes in the LV after RV apical pacing
Methods and Results: Six does underwent dual chamber pacemaker (DDD) implantation and atrioventricular nodal catheter ablation The pacing group received atria-sensed RV apical pacing for 12 weeks LV dyssynchrony was assessed with speckle tracking technique Subsequently. hearts were processed or Western blotting. Four sham-operated dogs were included tor comparison selleck After 12 weeks of RV pacing, cardiac Bromosporine purchase chamber size and LV ejection fraction remained unchanged Both electrical and mechanical dyssynchrony were evident in RV-paced dogs compared with sham-operated dogs The late-activated LV lateral wall of paced dogs displayed a 23% reduction in the amount of sarcoplasmic reticulum Ca(2+). ATPase, a 32% reduction in phospholamban levels, but a 3 6-fold increase in phospho-JNK expression, a 2 2-fold increase in phospho-p38, and 1 9-fold increase in phospho-ERK expression There were
no significant differences in the early-activated LV septum between paced and sham does
Conclusions: Temporal dispersion of mechanical activation by RV apical pacing induced spatial dispersion or protein expression in the LV. (1 Cardiac Fail 2010, 16 700-706)”
“Japanese encephalitis virus (JEV) causes Japanese encephalitis, which is a leading form of viral encephalitis in
Asia, with around 50,000 cases and 10,000 deaths per year in children below 15 years of age. The JEV has shown a tendency to extend to other geographic regions. Case fatality averages 30% and a high percentage of the survivors are left HDAC inhibitor with permanent neuropsychiatric sequelae. Currently, there is no cure for JEV, and treatment is mainly supportive. Patients are not infectious, but should avoid further mosquito bites. A number of antiviral agents have been investigated; however, none of these have convincingly been shown to improve the outcome of JEV. In this review, the current knowledge of the epidemiology and the pathogenesis of this deadly disease have been summarized. (C) 2012 Elsevier Editora Ltda. All rights reserved.”
“There are often discrepancies when using different methods to measure anti-Toxoplasma gondii IgG levels in patient samples. The diagnostic performance of a chemiluminescent immunoassay (CLIA) and an enzyme-linked fluorescent assay (ELFA) used as confirmatory tests for samples identified as positive or equivocal by an electrochemiluminescent immunoassay (ECLIA) were examined. Cut-off values were those stated by the manufacturer, and Western blot was used to confirm the results of all methods.