62 to 0.38 deaths/1,000 LB), followed by the North (β1 = -0.06). Among older children, the mean annual reduction in the coefficient of mortality ranged from 0.09 to 0.66 deaths/100,000 (Table 1 and Table 2). The North (5.6 deaths/100,000), Northeast (4.7 deaths/100,000), and Midwest (4.7 deaths/100,000) had, on average, higher values of mortality coefficients when compared to the South (1.4 deaths/100,000) and Southeast (1.3 deaths/100,000) during the ten-year study period. In 2000, the absolute number of HAAs paid in Brazil with ICD A09, for children younger than 1 year was 55,161, with a reduction of 52% of this value

in 2010 (26,347) and 14% increase (59,533 to 67,858) in children aged between 1 and 4 years. The rate of hospitalization for diarrhea in children Docetaxel younger than 1 year was nearly stable (slight mean annual decrease) in all regions throughout the series (Fig. 1B), with the highest reduction rate observed in the Northeast (β1 = -1.70 – reduction of 1.7 hospitalizations per thousand LB each year) (Table 1). Among older children, a stabilization trend was observed, with a non-significant increase (Fig. 2B), except in the Southeast, which presented a slight decrease in hospitalization rates (β1 = -0.13) (Table 2). The same pattern was observed regarding the percentage of estimated annual hospitalizations in both age groups in the last decade (Table 1 and Table 2); however, it could be observed

that the North and Northeast had more hospitalized children due to diarrhea, especially among children younger than 1 selleck year (Figure 1 and Figure 2). On average, the rate of hospitalizations among children younger than 1 year in the Northeast was 10.2% (standard deviation [SD] = 1.9%); in the North, 9.8% (SD = 1.2%); in the Southeast, 4% (SD = 1.3%); in the Midwest, 5.4% (SD = 1.0%); and in the South, 2.2% (SD = 0.3%). For older children, on average,

the rate of hospitalization in the Northeast was 10.7% (SD = 1.9%); in the North, 11.6% (SD = 1.5%); in the Southeast, 6.5% (SD = 1.0%); in the Midwest, 8.5% (SD = 1.5%); and in the South, Progesterone 5.3% (SD = 1.2%). The mean length of hospital stay during the study period was 4 days in those younger than 1 year and 3.4 days in children aged between 1 and 4 years, with a reduction of approximately 20% (0.85 days) between 2000 and 2010 in both age groups. Figure 1 and Figure 2 demonstrates that the mean length of stay is decreasing and homogeneous in all regions, except for the Midwest, which presented a heterogeneous pattern, especially in children younger than 1 year; however, the Midwest presented the highest estimated annual decrease, although negligible, in the mean length of stay (days) in both age groups (β1 = -0.18/β1 = -0.15) (Table 1 and Table 2). The mean value paid by HAA in 2000/2010 was R$ 405.36 (US$ 221.14)/R$ 368.43 (US$ 209.72) and R$ 360.12 (US$ 196.46)/R$ 347.62 (US$ 197.