This study investigates the potential of record linkage to enhance reporting of deaths among Aboriginal and Torres Strait Islander peoples
in NSW, Australia.
Methods: Australian Bureau of Statistics death registration data for 2007 were linked with four population health datasets Pevonedistat molecular weight relating to hospitalisations, emergency department attendances and births. Reporting of deaths was enhanced from linked records using two methods, and effects on patterns of demographic characteristics and mortality indicators were examined.
Results: Reporting of deaths increased by 34.5% using an algorithm based on a weight of evidence of a person being Aboriginal or Torres Strait Islander, and by 56.6% using an approach based on ‘at least one report’ of a person being Aboriginal or Torres Strait Islander. The increase was relatively greater in older persons and those living in less geographically Nirogacestat remote areas. Enhancement resulted in a reduction in the urban-remote differential in median age at death
and increases in standardised mortality ratios particularly for chronic conditions.
Conclusions: Record linkage creates a statistical construct that helps to correct under-reporting of deaths and potential bias in mortality statistics for Aboriginal and Torres Strait Islander peoples.”
“Purpose of review
The capacity of the liver to regenerate and maintain a constant size despite injury is unique. However, the exact mechanisms are not completely clear. Cell transplantation has been proposed as an alternative treatment of liver diseases. Recent progress has been reported on the generation of stem/progenitor SB203580 solubility dmso cells that may differentiate toward the hepatic lineage. However, it is currently difficult to determine which of the stem/progenitor cell populations are the best for therapy of a given disease.
Recent findings
The limited access to donor human hepatocytes has led to a great interest in the generation of hepatocyte-like cells. Several potential cell sources have been identified However, general standardization
of the methods to evaluate these cells is particularly important for the promise of stem/progenitor-derived hepatocyte-based therapies. Moreover, innovations aimed at improving hepatocyte delivery, survival, and engraftment have recently opened the field of organ engineering that may improve liver repopulation.
Summary
Here we review current evidence reported from the perspective of potential clinical applications of different hepatic cell sources with repopulation capacities and the future perspectives and tools that can facilitate the translation of laboratory work into clinical success.”
“To evaluate the feasibility and accuracy of diagnosis using sentinel node (SN) biopsy in T1 gastric cancer, a multicenter trial was conducted by the Japan Clinical Oncology Group (JCOG).
Sentinel node biopsy with indocyanine green (ICG) was performed in patients with T1 gastric cancer.