The results indicate that dimensions of the face space are encoded in the face-selective brain areas in a spatially distributed way. (C) 2013 Elsevier Ltd. All rights reserved.”
“In Saccharomyces cerevisiae, Stn1p and Ten1p are required for telomere maintenance. These two proteins and another telomeric single-stranded DNA binding protein, Cdc13p, have been

proposed to form a complex to control telomere integrity. In this work, we purified the recombinant stn1p in Escherichia LDN-193189 mw coli and found that the purified protein could specifically interact with single-stranded telomeric DNA in vitro. Co-fractionation of co-overexpressed stn1p and Ten1p in insect cells revealed their stable association. A stn1p/Ten1p binary complex was reconstituted with purified recombinant

proteins in vitro. These results indicated that stn1p and Ten1p interact with each other directly, which is important CB-839 in telomere length regulation and end protection. (C) 2010 Elsevier Inc. All rights reserved.”
“Face processing is limited in scope as a function of experience – discrimination ability and face-specific behavioral effects are reduced in out-group faces. Nonetheless, other-species faces phylogenetically close to our own may be processed by similar mechanisms as human faces. Presently, we asked whether or not the well-known effect of contrast-negation on face recognition (Galper, 1970) was exclusive to human faces or generalized to monkey faces. Negation disrupts face pigmentation substantially, allowing us to examine species-specific use of surface cues as a function of expertise. We tested adult observers behaviorally and electrophysiologically: participants completed a 4AFC discrimination task subject to manipulations of face species and independent negation of image luminance and image chroma, and the same stimuli were used to collect event-related potentials in a go/no-go task. We predicted that expertise for human faces

would lead to larger deleterious effects of negation for human faces in both tasks, reflected Baricitinib in longer RTs for correct responses in the discrimination task and species-specific modulation of the N170 and P200 by contrast-negation. Our results however, indicate that behaviorally, luminance and chroma negation affect discrimination performance in a species-independent manner, while similar effects of contrast-negation effects are evident in each species at different components of the ERP response. (C) 2013 Elsevier Ltd. All rights reserved.”
“An expression system is described for the production of monomeric scFvs and scFv antibody fragments genetically fused to human albumin (at either the N- or C-terminus or both). Based upon strains of Saccharomyces cerevisiae originally developed for the production of a recombinant human albumin (Recombumin (R)) this system has delivered high levels of secreted product into the supernatant of shake flask and high cell density fed-batch fermentations.