The patient was alive and well for 1 month after systemic antibiotics treatment with catheter drainage for peudocyst. On follow-up CT showed an interval decrease in size of the pseudocyst. Key Word(s): 1. IPMN;

2. pseudomyxoma; 3. pseudocyst; Presenting Author: ZHONGGU PING Corresponding Author: ZHONGGU PING Affiliations: yichun Objective: To study diagnosis of early diabetes-related pancreatic cancer. Methods: 117 cases of pancreatic cancer, 126 cases of diabetes, and 156 cases of gastrointestinal cancer were included in this case-control study for the comparison of diabetes case and serum Amyloid polypeptide (IAPP). Results: 22 cases of diabetes were in 117 cases of pancreatic cancer and 3 cases of diabetes were in 156 cases of gastrointestinal cancer, Acalabrutinib mw the difference was statistically significant. 19 of 22 (86.3%) pancreatic cancer cases with diabetes which course of diabetes were less more than 2 years, however course of type 2 diabetes patients were most than 2 years (105/126, 83.3%) alwalys. The content of IAPP in pancreatic cancer with diabetes group, gastrointestinal cancer group and type 2 diabetes

group was respectively 21.2±11.4, 7.3±3.2 and 3.7 check details ±2.8 (pmol/L). Conclusion: Pancreatic cancer patients, especially accompanying a history of less than 2 years with type 2 diabetes, might have abnormal glucose metabolism in early. The detection of serum IAPP would also help the early diagnosis of pancreatic cancer. Key Word(s): 1. pancreatic 上海皓元医药股份有限公司 cancer; 2. diabetes-related ; 3. early diagnosis; Presenting Author: YIQI DU Additional Authors: MINGHAO LIU, JUN GAO, ZHAOSHEN LI Corresponding Author: YIQI DU Affiliations: Changhai Hospital, Second Military Medical University Objective: MiR-196a levels inversely correlated with survival in pancreatic adenocarcinoma patients. However, the functional contributions of miR-196a to pancreatic cancer remain unclear. Methods: Three lentiviral vectors encoding microRNA miR-196a precursor,

inhibitor and scrambled miRNA oligomer were transfected into Panc-1 cells, respectively. Then we explored the regulation of inhibitor of growth 5(ING5) expression by miR-196a and its impact on apoptosis, invasion and growth of pancreatic cancer cells. The lentiviral transfected Panc-1 cells were surgically implanted into the pancreas of mice. In vivo tumor growth and ING5 expression were measured. Results: Down-regulation of ING5 expression was detected in cells transfected with miR-196a precursor (P<0.01), accompanied by less apoptosis, increased invasion and proliferation compared to control cells (P<0.05). Cells transfected with miR-196a inhibitor revealed an opposite trend(Fig 1). Smaller detectable tumors were found in only 60% of mice after implantation of Lenti. miR-196a inhibitor – transfected Panc-1 cells compared to controls (360.7±303.6 mm∧3 versus < 511.58±365.9 mm∧3 in controls; P<0.01, Fig 2).