The European Vertebral Osteoporosis Study [7] found an overall similar frequency of vertebral deformities in their study in 19 European countries, but their sample did not include subjects older

than 75 years of age, whereas the substantial increments of vertebral fractures are found in other studies. A higher incidence of vertebral fracture in men was reported in the Rotterdam study, and the incidence increased with age [20]. Similar results were found in the LDN-193189 datasheet EPOS study where the rate of incidence of morphometric fracture was 9.9 in 1,000 women aged 50-79 per year, with a rate approximately Cell Cycle inhibitor one-half which is 5.7 in 1,000 men per year [21]. Differences in the prevalence between genders have also been reported in the United States (14% in men and 19% in women [22] In

Asia, the prevalence in women 65 years and over was 20% (18–22%) and in men, 12.5% (11–14%) [23]. We conclude that vertebral fractures are more frequent in older age Mexican men, and these figures have to be taken into consideration by Mexican health authorities as they plan future programs oriented to prevent and treat fragility fractures in men. Included in our questionnaire were several clinical risk factors known to be associated with osteoporosis and fractures, but we were not able to demonstrate differences between the fracture and nonfracture group. The fracture group had a higher frequency of self-reported height loss, however, only see more a tendency of this was shown in the bivariate and multivariate analysis. This study has several strengths. The results were based on a random community sample and there was a high rate of participation. This study followed the standardized approaches for recruiting participants, obtaining X-rays, and assessing potential

risk factors, and all of the films were assessed centrally using the same methods that have been employed in international studies and in the LAVOS study [6]. Our study also had limitations. It was not specifically designed to characterize the risk factors for vertebral fracture in men; therefore, the sample size was not large enough to find significant association Ponatinib price with the risk. As it was a cross-sectional study, we could not assess the association of pain or symptoms with vertebral fractures. In conclusion, vertebral fractures in Mexican men over 50 years are frequent, it increases with age, and the rise stops after the age of 70 years. Compared with Mexican women, the prevalence of men with vertebral fractures is half that reported for Mexican women using the same methodology (9.7 vs. 19.2, respectively). This pattern of presentation is similar to that reported for other countries. These figures should alert clinicians and health authorities to this health problem in older Mexican men.