The aim of this post-hoc analysis was to investigate the effects of add-on therapy with calcium channel blockers (CCBs) on changes in the composite ranking of relative risk according to KDIGO guidelines. Benidipine, an L- and T-type CCB, and amlodipine, an L-type CCB to angiotensin PR 171 II receptor blocker (ARB), were examined. Methods: Patients with blood pressure (BP) >130/80 mmHg, an estimated GFR (eGFR) of 30–90 mL/min/1.73 m2, and albuminuria >30 mg/gCr, despite treatment with the maximum recommended dose of ARB, were randomly assigned to two groups. Each group received one of
two treatments: 2 mg benidipine daily, increased to 8 mg daily (n = 52), or 2.5 mg amlodipine daily, increased to 10 mg daily (n = 52). Results: The final doses of benidipine and amlodipine were 6.3 ± 0.3 and 5.4 ± 0.4 mg per day, respectively. After 6 months of treatment, a significant AZD9668 manufacturer and comparable reduction in systolic and diastolic BP was observed in both groups. The eGFR was significantly decreased in the amlodipine group, but there was no significant change in the benidipine group. The decrease in albuminuria in the benidipine group was significantly lower than in the amlodipine group. The composite ranking of relative risk according to the new KDIGO guidelines was significantly improved in the benidipine group; however,
no significant change ADP ribosylation factor was noted in the amlodipine group. Moreover, significantly fewer cases in the benidipine group than the amlodipine group showed a reduced risk category score. Conclusion: The present post-hoc analysis showed that compared to
amlodipine benidipine results in a greater reduction in albuminuria accompanied by an improved composite ranking of relative risk according to the KDIGO CKD severity classification. TEO BOON WEE1,2, TOH QI CHUN1, LAU TITUS2, YANG ADONSIA1, LIN TINGXUAN1, SETHI SUNIL1,2 1National University of Singapore; 2National University Health System Introduction: Stable chronic kidney disease (CKD) patients retain sodium and water which increases intravascular fluid volume, leading to myocardial stretching and release of B-type natriuretic peptide (BNP). The profile of BNP levels in Asian CKD patients is unclear. We assessed serum BNP levels in a multiethnic-Asian population of stable CKD patients. Methods: We prospectively recruited stable CKD patient (defined as serum creatinine not >20% over 3 months) and performed anthropometry, office blood pressure measurements (Dinamap) according to practice guidelines, and venepuncture. Blood samples were assayed for BNP (Abbott), and creatinine to estimate glomerular filtration rate (eGFR) with the CKD-EPI equation. Data are reported as mean ± SD, or median and interquartile range, where appropriate. Non-normally distributed data were natural log-transformed for analyses.