Student’s t-tests did not reveal a relation between NE and any of the nonpsychotic subcategories. ANCOVA without the subcategories as fixed factors showed that plasma NE concentration in the whole group of 78 towards patients was not related to the dosages of antipsychotic, benzodiazepine and antidepressant drugs (F= 0.042, p = 0.838; F = 0.042, p = 0.838; F = 0.0274, p = 0.602 respectively). However, the NE concentration appeared to depend significantly

on smoking habit and tricyclic treatment. Smoking habit was negatively related to NE (F = 6.826, p = 0.011) and positively related to tricyclic treatment (F = 6.448; p = 0.013). The SSRI and Inhibitors,research,lifescience,medical SNRI treatments were not related. The addition of age and sex to the ANCOVA model resulted in a significant relation with Inhibitors,research,lifescience,medical age (F = 4.128, p = 0.046) that slightly reduced the strength of the relation with smoking habit (F = 6.653, p = 0.012), while no relation was found between NE and sex (F = 0.085, p = 0.771). Table 1. Mean concentration of plasma norepinephrine (pg/ml) and standard DOT1L deviation in major depressive disorder, psychotic depression

and three other subcategories. ANCOVA in the 75 patients with complete NE and AVP data, using NE as a dependent variable, the subcategories of melancholic, Inhibitors,research,lifescience,medical HAR and ANA depression as fixed factors, and smoking habit, age and tricyclic treatment, and the three nonpsychotic dimensions of Emotional Dysregulation, Retardation and Anxiety as covariates, Inhibitors,research,lifescience,medical showed that NE was still negatively related to smoking habit (F = 8.525, p = 0.0054) and positively related to tricyclic treatment (F = 10.146, p = 0.002), but no longer with age (F = 0.628, p = 0.431). The HAR subcategory was negatively related to plasma NE (F = 4.786, p = 0.032), and the dimensions of Retardation and Anxiety were each positively related to NE (F = 5.372, p = 0.024; F = 7.315, p = 0.009 respectively). The dimension of Emotional Dysregulation was not related to NE (F = 1.058, p = 0.307). Duration of present episode and inpatient or outpatient Inhibitors,research,lifescience,medical treatment were not

related to NE. In conclusion, smoking habit, tricyclic treatment and HAR depression were found to be related to plasma NE. The intensity of the dimension of Emotional Dysregulation that specifically relates GSK-3 to PSDEP was not related to plasma NE, while the dimensions of Retardation and Anxiety that were not related to PSDEP, related to NE. The dimension of Emotional Dysregulation could therefore be used to test if the severity of depression that is an inherent aspect of PSDEP is involved in the relation between NE and PSDEP. Smoking habit and tricyclic treatment were subsequently used as other potential confounders in the analyses involving NE and PSDEP, as were the other two global dimensions of psychopathology and the HAR subcategory.