Since endogenous ERPs depend on subjects’ attention to contextual stimuli and intentionality, they seem more suitable to be used in BCIs, with respect to exogenous ones. Figure 2 A schematic representation of some components of an ERP. Figure 3 A P300 BCI mTOR inhibitor session. The P300 is a deflection in the EEG that occurs 200–700 msec after stimulus onset and is typically recorded over central-parietal scalp locations (Fabiani et al. 1987). The response is evoked by attention to rare or surprising, task-relevant stimuli in a Inhibitors,research,lifescience,medical random series of stimulus

events (Fabiani et al. 1987), by mean of a simple discrimination task. In this “oddball paradigm” (Farwell and Donchin 1988), two stimuli are presented in a random order such as one of them occurs relatively infrequently, that is the oddball. The subjects are required to discriminate the infrequent target stimulus from Inhibitors,research,lifescience,medical the frequent standard stimulus, by responding covertly or overtly to the target. Subjects can be instructed

to mentally count the target stimuli or to provide an overt response, such as pressing a button or make a finger movement when a target stimulus is detected. Events from the rare category elicit the P300 component of the ERP. Inhibitors,research,lifescience,medical Besides, a modification of the oddball task is the three-stimulus paradigm, in which infrequent distractor Inhibitors,research,lifescience,medical stimuli are inserted into the sequence of target and standard stimuli. In this case, a novelty P300 can be produced, named P3a, which is an early peak, large over the frontal and central areas and

is thought to reflect frontal lobe function. P3a can be elicited also for typical, rather than novel, stimuli, when the perceptual distinctiveness between the target and the standard stimulus is quite difficult and the distractor stimulus is not novel, but highly discrepant. On the contrary, P300 arising from the target stimulus detection is a later Inhibitors,research,lifescience,medical peak with a large parietal amplitude, and has been called P3b, which is synonymous with P300 (Polich 2004). While P3a is produced when a demanding stimulus MRIP automatically drives frontal lobe mediated attention, P3b is produced when attentional resources are intentionally allocated for stimulus classification. From a neuroanatomical point of view, the P3a is thought to reflect activity of the anterior cingulate gyrus when new stimuli are processed into working memory. The P3b is thought to reflect subsequent activation of the hippocampal formation when frontal lobe mechanisms interact with the temporal/parietal lobe connection (Polich 2007; Verleger 2008). High task difficulty increases focal attention and enhances P3a amplitude by constraining other memory operations that reduce P3b amplitude and increase P3b latency (Hagen et al. 2006). Most P300 clinical studies have employed the P3b subcomponent.