Our data is constituent with the previous study by Carson et al.22) They concluded that clinically apparent PE was an uncommon cause of death and most deaths were due to underlying diseases like cancer, heart failure or chronic lung disease. Limitations This is an observational study with analysis of relatively small numbers of stored digital images. Bias may

have been introduced from patient selection. Analysis may have been affected by image quality. Second, we assessed RV systolic function by RVFAC in the differentiation of RV systolic dysfunction. Other more accurate and objective imaging modalities, such as cardiac magnetic resonance imaging Inhibitors,research,lifescience,medical or RV angiography, would have increased this study’s reliability. Unfortunately, patients with Inhibitors,research,lifescience,medical acute PE usually PI3K inhibitor needed intensive therapy and were not suitable for these imaging studies in their presentation. A prospective study with a larger number of patients and using different echocardiographic machines at the same time will be needed to confirm the correlations and the clinical impact of this measurement. Conclusion TAPSE and TASV showed

significant correlations with conventional echocardiographic parameters of RV function and LogBNP value. These values can be used Inhibitors,research,lifescience,medical to detect RV systolic dysfunction more easily in patients with acute PE.
REFER TO THE PAGE 174-180 Recently, dynamic left ventricular dyssynchrony (LVD) using exercise echocardiography (ExE) become a promising method in many cardiovascular disease, because it can Inhibitors,research,lifescience,medical unveil the pathophysiology, can predict the prognosis and also would be a possible

surrogate marker in the treatment monitoring.1),2) Especially in the field of cardiac resynchronization therapy, it would be a useful tool for patient selection, the prediction of response and optimization Inhibitors,research,lifescience,medical method during exercise.3) Although dynamic LVD can be measured by simply manipulating loading condition using sublingual nitroglycerine and leg-raising maneuver,4),5) ExE can be provide more additional information about myocardial ischemia, diastolic function, pulmonary hypertension and exercise capacity. The presence of left ventricular hypertrophy (LVH) and concentric remodeling is related to Resminostat the prognosis of hypertensive patients. However, there were few report about the relationship of LVH and dynamic LVD. Seo et al.6) reported that systolic LVD during exercise is significantly associated with the degree of LVH in hypertensive patients. Although dyssynchrony was impaired in both LVH and non-LVH group at resting, exercise could differentiate these. Systolic and diastolic dyssynchrony were exaggerated more in LVH group compared to non-LVH one. And, as we expected, the presence of LVH could limit the exercise duration even adjusting for age, sex and diastolic dysfunction. It means ExE can provide a valuable suggestion between the pathophysiology of hypertensive LVH and exertional dyspnea.