In this study, based on the growth curve, cell cycle, and telomerase activity analyses, MSCs derived from AT-MSCs possess the highest proliferation potential, Vismodegib medulloblastoma followed by MSCs derived from bone marrow and cartilage. In terms of multilineage differentiation, MSCs from all three sources have displayed osteogenic, adipogenic, and chondrogenic differentiation potential. Flow cytometry and MTT analysis have showed that cartilage-MSCs possess the highest resistance toward H2O2-induced apoptosis, while AT-MSCs have exhibited high tolerance to serum-deprivation-induced apoptosis. Authors concluded that adipose tissue and cartilage are attractive alternatives to bone marrow as sources for isolating MSCs [7].To our knowledge there is only a single in vivo study comparing fate and function of adipose stromal cells (ASCs) in the infarcted heart directly to BM-derived MSCs.

ASCs and MSCs were isolated from transgenic FVB mice. Unfortunately, the authors concluded that ASCs and MSCs did not tolerate well in the cardiac environment, resulting in acute donor cell death and a subsequent loss of cardiac function similar to control groups [20]. hAT-derived MSCs have not yet been compared directly to hBM-derived MSCs in clinical studies.The results of this study suggest that hAT may represent an ideal source of autologous stem cells for stem cell treatment. However, the process of bone marrow harvesting can be painful and quantity of cells that can be harvested from the patient is limited. Liposuction may be a good choice for adipose tissue harvesting.

hAT-derived MSCs largely express the same surface markers as BM-MSC and have shown to preserve cardiac function after infarction [21].8. ConclusionThe ability to resist stress and apoptosis is an important phenomenon for survival. This is especially important in stem cell studies during which stem cells are being injected to a damaged area for recovery purposes. If a stem cell is more prone to apoptosis, the change of survival during clinical practice would be less. Therefore, stem cells selected for clinical studies should be checked for their survival rate under stres conditions. In this study we found that hAT-MSCs are more resistant to in vitro apoptosis.Conflict of InterestsThe authors declare that they have no conflict of interests.
The number of identifiable DNA sequences responsible for various physiological structures is rapidly increasing as more and more collected DNA sequences are added to scientific databases. It is, however, difficult to obtain information directly from sequences since the sheer volume of data is computational demanding. It is one of the challenges for biologists to analyze mathematically the large volume of Cilengitide genomic DNA sequence data.