Hui KC, Ong HC, Lee PF, Dai JY: Effects of AlOx-cap layer on the luminescence and photoconductivity of ZnO thin films. Appl Phys Lett 2005, 86:152116.CrossRef 55. Jiao Y, Zhu HJ, Wang XF, Shi L, Liu Y, Peng LM, Li Q: A simple route to controllable growth of

ZnO nanorod arrays on conducting substrates. Cryst Eng Comm 2010, 12:940–946.CrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions SK carried out the experimental parts on the sample preparation and characterization and drafted the manuscript. CF and SA participated in the statistical analysis and revised the manuscript. All authors read and approved the final manuscript.”
“Background Chemotherapy is an important method of adjuvant therapy for pancreatic cancer. Gemcitabine, 2′,2′-difluoro-2′-deoxycytidine, see more remains the standard of use and has more significant clinical check details benefit than fluorouracil (5-FU) (clinical benefit response, 23.8% of gemcitabine treated patients vs. 4.8% of 5-FU-treated patients, p = 0.0022) [1, 2]. However, gemcitabine has a short half-life in vivo and will be rapidly and extensively decomposed to inactive products in the blood, liver, kidney, and other tissues by cytidine deaminase [3]. For example, at the standard dose of 1,000 mg/m2, a patient’s plasma gemcitabine

concentration dropped to only 0.4 μg/mL in 1 h after intravenous infusion, considerably below the 5-μg/mL optimal plasma concentration for cancer cell inhibition [4]. Thus, a larger dose is necessary, while it poses a greater risk of side effects. It has been documented BAY 80-6946 concentration that change in the formulation of gemcitabine might be a way to reduce side effects and improve the drug biopharmaceutical features [5]. For example, Paolino et al. found that gemcitabine-loaded PEGylated unilamellar liposomes could promote the concentration of the drug inside the tumor and increase the plasmatic half-life of gemcitabine [3]. Moreover, this formulation did not display Tyrosine-protein kinase BLK any blood toxicity. Of the various formulations available, nanospheres with a mean diameter of 10 to 1,000 nm are

widely used as carriers in drug delivery systems in clinical applications [6, 7]. They have some potential chemotherapeutic advantages for the treatment of tumors, including pancreatic cancer. Firstly, they can be biodegradable after intravenous injection. Secondly, owing to enhanced permeability and retention (EPR) effects, nanospheres loaded with drugs can release drugs slowly and deposit them in the target organ so that their toxicity would be enhanced in tumor tissues while reduced in normal tissues [8–10]. Furthermore, tumor cells, Kupffer cells, and mononuclear phagocyte system have higher phagocytotic rates for uptaking nanoparticles than other tissue cells. Therefore, the nanospheres loaded with drugs could be targeted to tumor, the liver, or spleen [11].