Change in C ring configuration (isoaurones) resulted in lower IP and O-H BDE value at C-6. The current findings suggest that aurones deserve more attention for food or pharmaceutical applications as antioxidants. (C) 2010 Elsevier Ltd. All rights reserved.”
“The star-shaped polymethylmethacrylate (PMMA) was synthesized via radical polymerization promoted

by metallocene complexes in the presence of initiator of tetra(2,3-epoxy propoxy)silane (Is) and reducing agent Zn. The effect of temperature, time, molar ratio of monomer to initiator, and the structure of metallocene complexes on the polymerization SNX-5422 mouse performance was investigated. The structure and properties of the obtained polymer were characterized by gel permeation chromatography, multiangle laser light scattering, (1)H NMR, (13)C NMR, and WAXD. The results indicated that the obtained polymer was atacticspecific and featured narrow molecular weight distribution (1.30-1.57). Star-shaped Smoothened Agonist organosiloxane-functionalized PMMA was produced. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 1652-1658, 2011″
“This audit examined outcomes for 203 patients prescribed zonisamide (ZNS) for various uncontrolled seizure types at a

specialist outpatient service. Forty-two (20.7%) patients achieved 6 months of seizure freedom, and an additional 37 (18.2%) had a >= 50% seizure reduction for 6 months on a stable ZNS dose. Seizure freedom was more likely in patients with primary generalized (24/61, 39%) than in those with partial-onset (18/141, 12.7%) seizures (P < 0.001). Eight patients

(5 seizure free) were maintained on ZNS monotherapy. More patients became seizure free with ZNS as monotherapy or first add-on, compared with those in whom ZNS was the second, third, or fourth adjunctive drug (P = 0.001). Seizure freedom was less likely in patients treated with hepatic enzyme-inducing agents (13/113, 11.5%) than in those receiving noninducing AEDs (24/82, 29.3%) (P = 0.002). ZNS was discontinued in 72 (35.5%) patients largely because of side effects (n = 58, 28.6%). Commonest complaints leading to withdrawal were sedation (n = 14), nausea and vomiting (n = 13), neuropsychiatric symptoms (n = 12), rash (n = 6), and weight loss (n = 6). OICR-9429 mouse Around 80% of patients who became seizure free on ZNS or had the drug withdrawn did so on a dose <= 200 mg. ZNS is an effective broad-spectrum AED that can also produce a range of dose-dependent and idiosyncratic side effects. (C) 2010 Elsevier Inc. All rights reserved.”
“Recently, we have shown that seed shells contain a large amount of highly polymeric proanthocyanidins having a series of heteropolyflavan-3-ols with doubly linked A-type linkages as well as single B-type bonds without gallic acid esterified to them. Here, we attempted to evaluate in vivo anti-obesity effects of the polymerized proanthocyanidins in mice.