c) ECG – rate, rhythm, axis, QRS duration, PR and corrected QT interval,

and presence of any of the following: premature atrial or ventricular beats, blocks, ventricular hypertrophy, old myocardial infarction, new ischemic changes, or others (delta waves, changes consistent with Brugada syndrome, arrhythmogenic Inhibitors,research,lifescience,medical right ventricular dysplasia); and c) Cardiac monitor : Duration of monitoring, arrhythmia detected and symptoms associated with the arrhythmia. 5. Variables for Disposition and Physician Judgment: a) Final diagnosis in ED – vasovagal, orthostatic hypotension, likely cardiac, cause unknown, or outcome in the ED or pre-hospital setting; b) Certainty of diagnosis in ED – scaled from 0 to 100% by the deciles; c) Probability of SAE occurring within 30 days after leaving the ED – scaled from 0-5% by each percentile, 10-50% by the Inhibitors,research,lifescience,medical deciles, 75% and 100%; d) Referral: Specialty to which patient was referred (e.g., cardiology, or neurology) and when (in ED or as outpatient), disposition

of the patient; e) Outpatient investigations organized – holter, echocardiogram or others; and e) Definitive Treatment – Did the patient/family decline definitive treatment? Interobserver reliability Inhibitors,research,lifescience,medical Inhibitors,research,lifescience,medical Whenever possible, a second emergency physician blinded to the findings of the first assessor will collect variables on the physician data collection form approximately in 10% of the study patients. This second physician will obtain consent from the patient and will ABT 378 explicitly inform the patient that the assessment is being done purely

for research purposes. Quality assurance Feedback will be given to physicians regarding any issues with their data collection or recording. We will not provide physicians with information regarding the accuracy or Inhibitors,research,lifescience,medical reliability of the individual variables. Ethical considerations We have obtained ethics approval from the research ethics boards of all the study hospitals. All personal identifiers will be kept strictly confidential and stored separately from the clinical information collected. We will also explicitly advise physicians not to alter their patient care for the study, but Calpain to continue with usual care. As there is no change in patient management, this study poses no threat to patient safety. This study is approved by the Research Ethics Boards of all the study hospitals. Outcomes The primary, secondary and long-tem (1-year) outcome measures are detailed in Prospective Multicentre ED Syncope Study: List of Serious Adverse Events and their Definitions.