(C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“We examined memory performance and cortical source localization of old/new effects in a source memory task in

obsessive-compulsive disorder (OCD) patients by employing an equivalent current dipole (ECD) model using EEG and a realistic head model. Event-related potentials see more (ERN) were recorded while 14 OCD patients and 14 age-, sex-, handedness-, and educational level-matched healthy control subjects performed recognition tasks for spoken words (items) or for the voice of the speaker of spoken words (sources). In the item memory task, both groups showed ERP old/new effects at 300-700 ms. In the source memory task, the controls showed ERP old/new effects at 400-700 ms, whereas THZ1 solubility dmso the OCD patients did not. Compared with the controls, the OCD patients showed significantly lower source accuracy and prolonged

reaction times to the old words with accurate voice judgments. There were no differences between the OCD and control groups with regard to the locations of the ERP generators elicited by source correct and correct rejection conditions. The OCD patients showed significantly altered hemispheric asymmetry of ECD power in the frontal lobe during source memory retrieval, compared with the controls. These results indicate that OCD patients have preserved item memory about content, but impaired Source memory about context. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“Common fragile sites (CFSs) were characterized almost 30 years ago as sites undergoing genomic instability in cancer. Recently, in vitro studies have found that oncogene-induced

replication stress leads to CFS instability. In vivo, CFSs were found to be preferentially unstable during early stages of cancer development and to leave a unique signature of instability. It is now found increasingly clear that, along the spectrum of replication features characterizing CFSs, failure of origin activation is a common feature. This and other features of CFSs, together with the replication stress characterizing early stages of cancer development, lead to incomplete replication that results in genomic instability preferentially at CFSs. Here, we review the shared and unique characteristics of CFSs, their underlying causes and their implications, particularly with respect to the development of cancer.”
“Objective: As a common disease, the molecular etiology of noninherited vascular anomalies is still poorly understood. Recently, somatic mutations in exon 17 of the endothelial cell tyrosine kinase receptor Tie-2 (encoded by TEK) were identified in 49.1% of patients with common sporadic venous malformation, a subtype of vascular anomalies.