, 2013). All participants gave written informed consent, and the study was approved by local ethics committees. The FITC task (Fig. 1) was modelled after Horstmann and Bauland (2006) and used angry/happy photographs from the Pictures of Facial Affect (Ekman & Friesen, 1975), modified to ensure equal recognisability and emotional arousal as described in Schmidt-Daffy (2011). As in a previous study (Horstmann & GSK2118436 chemical structure Bauland, 2006), photographs from one actor (MF) were used. On each trial, participants had to indicate whether a target face (angry or happy) was present in an array of 1, 6, or 12 faces. On

half of the trials, exactly one of these faces showed the target expression on the remaining trials (present trials), and none of the faces showed the target expression (absent trials). This means the task is to detect a target BGB324 manufacturer expression in a crowd of faces with the opposite expression, all with the same face identity. Each face was presented with a visual angle of 1.05° (width) × 1.43° (height). Possible stimulus locations were based on an (invisible) 4 (horizontal) × 3 (vertical) array, in which locations

had a horizontal distance of 1.86° and a vertical distance of 1.43° from each other. On each presentation, 1, 6, or 12 locations were randomly chosen from this array. Target location was randomly assigned to one of these positions. Actual locations then slightly deviated from the array by randomly adding either −.14°, 0°, or .14° to the array location both in horizontal and in vertical direction. Faces were presented such that their centres corresponded to the resulting locations. The maximum screen area spanned by the array was 6.89° (width) × 4.57° (height). We presented 300 trials in two blocks, separated by a short break. Participants made a two-alternative forced choice whether

the target was present or absent, using the computer keyboard. Target emotion was angry for one block and happy for the other. Block order was randomised across healthy participants; AM started with happy target and BG with angry target. PRKD3 Thus, simple order effects would not result in a group difference between patients and control participants. The target face was shown on its own once before each block, but it was not verbally described. Participants were not asked to verbally describe the facial expression at any stage of the experiment. After presenting the target face, 20 practise trials with feedback followed which were not analysed, and then the experimental trials of the block started. Feedback was given only during practise trials. Each trial started with a 1100 msec fixation cross, followed by the face display which was on until the participant made a response. After the response, the next trial started immediately.