17 Figure 3 Estech COBRA Fusion™ System. SURGICAL

APPROACHES In the past decade, several surgical ablation approaches to treat atrial fibrillation as a stand-alone or concomitantly with other cardiac surgical procedures were developed.1–6,24–31 The use of the heart–lung machine is required to perform the Cox maze procedure in its current form and with the available ablation devices.1–3 It can be performed as a full selleck Sorafenib sternotomy or minimally invasive procedure.1-6,24–31 If other procedures such as valve repair/replacement or coronary bypass are to be performed concurrently with the Cox maze Inhibitors,research,lifescience,medical procedure, then the standard open chest Ruxolitinib JAK inhibitor approach is likely to be used; however, when atrial septal defect closure, Inhibitors,research,lifescience,medical mitral valve repair or replacement, and tricuspid valve surgery are required, a minimally invasive right mini-thoracotomy can be applied.1–6,24–31 The overall operative risk is low in morbidity and mortality and might be impacted by the individual’s specific health conditions.8–10 Cox Maze Procedure by Mini-Thoracotomy Despite the proven efficacy of surgical ablation, Inhibitors,research,lifescience,medical a fraction of patients and referring physicians are still unwilling to tolerate sternotomy for an arrhythmia-corrective procedure.18 This has led to the development and evaluation of minimally invasive surgical ablation

procedures. The term “minimally invasive” as Inhibitors,research,lifescience,medical it applies to cardiac surgery incorporates a combination of small, sternum-sparing incisions, alternative cannulation techniques, modified instruments, thoracoscopic visualization, and robotic assistance. Given that the Cox maze III has a proven track record for sinus restoration and improved quality of life, surgeons must be careful in performing a minimally invasive procedure with inferior results, particularly in those with non-paroxysmal

atrial fibrillation. Inhibitors,research,lifescience,medical The two current major strategies are a complete Cox maze III using minimally invasive approach and totally endoscopic left-sided surgical ablation approach. PROCEDURE Briefly, our approach is described here. We use double-lumen endotracheal intubation Anacetrapib for selective right-lung deflation. The patient is placed in the supine position with a single towel roll underneath the posterior right rib cage. The right shoulder is abducted and arm is flexed and secured to an arm bar. A 5–6 cm incision is placed beneath the right breast, and the right chest is entered through the fourth or fifth intercostal space. CO2 insufflation is used. The pericardium is opened approximately 2 cm anterior to the phrenic nerve. The pericardium is secured to the chest wall for retraction, and umbilical tapes are placed around the superior vena cava (SVC) and inferior vena cava (IVC). The right femoral artery and femoral vein are exposed through a 3 cm oblique groin incision, heparin is administered, and vessels are cannulated.