00001 as shown in the Forrest Plot diagram. Conclusion: The metaanalysis results significantly favored the use of Omeprazole + Amoxicillin + Levofloxacin over the standard triple therapy of Omeprazole + Amoxicillin + Clarithromycin in eradicating H. Pylori infection. A triple drug regimen RG7420 price consisting of Omeprazole, Amoxicillin and Levofloxacin may be considered a better first-line treatment option for HP eradication in this country. Key Word(s): 1. Helicobacter Pylori; 2. Clarithromycin; 3. Levofloxacin; 4. Eradication; Presenting Author: VIDIORBA BUSRO Additional Authors: FUADORBA BUSRO, YUWONO BAKRY, AIDA FARIDA Corresponding Author: FUADORBA BUSRO,

YUWONO BAKRY, AIDA FARIDA Affiliations: dr. muhammad husin general hospital IDH inhibition Objective: Over 90% of chronic gastritis cases

are caused by Helicobacter pylori, and half of those patients show no clinical symptoms. Poor environmental sanitation, low socioeconomic status and malnutrion are playing important role of this infection. This study aim to assess the sensitivity and specificity value of saliva Helicobacter pylori examination in chronic gastritis patients. It was expected that the result of the study could be applied as basic scientific methods to develop a noninvasive detection to confirmed the existence of Helicobacter pylori infection in chronic gastritis besides urea breath test (UBT). Methods: The subjects of the study were adult male and female, in and out patients that have dyspepsia symptoms over 6 moths. There were 50 subjects (26 male and 24 female) followed this study from June 2010 until March 2011. The PCR methods applied in identifying the DNA sequences of Helicobacter pylori in chronic gastritis patients’ saliva is a modification of Hakayama’s methods. The result of bacteria DNA sequencing is 16 s RNA that is located in 100 bp. Results: The histopathology result in this study show that among the subjects who experiencing chronic dyspepsia there were 16 subjects (32%) positive for Protirelin Helicobacter pylori and 34 subjects (68%) negative for Helicobacter pylori. There were 27 subjects (44%) were chronic active gastritis with intestinal metaplasia,

15 subjects (30%) were chronic active gastritis- Helicobacter pylori positive with intestinal metaplasia, 7 subjects (14%) were chronic non-active gastritis with intestinal metaplasia and 1 subjects (2%) were chronic non-active gastritis-Helicobacter pylori positive with intestinal metaplasia and atrophic. The result of the DNA sequences of chronic gastritis patients’ saliva using PCR show 47 subjects (94%) had positive result for Helicobacter pylori DNA sequence that consist of 23 male (46%) and 24 female (48%) subjects, while 3 subjects (all male) had negative result for Helicobacter pylori DNA sequences. Sensitivity and specificity values of Helicobacter pylori DNA sequences in saliva examination was 93.75% and 5.8% respectively with positive prediction value 31.9% and negative prediction value 66.67%.