In addition, other than the report by Kramer et al. [30], with its noted limitations, no population-level data reported on the epidemiology of PASS

across the full spectrum of pregnancy outcomes, including induced abortion, miscarriage, antepartum and postpartum hospitalizations. Only one study to date Wnt inhibition has described trends of the incidence of PASS. Bauer et al. [33] reported that the incidence of PASS rose 10% per year between 1998 and 2008. The incidence of PASS increased from 7 to 14 hospitalizations per 100,000 deliveries over study period. However, the sources of rising incidence of PASS remain unclear. Several investigators have noted the rising incidence of conditions and procedures leading to maternal severe sepsis and septic shock, including rising maternal age, obesity, chronic illness, use of cesarean section, and use of invasive procedures [25]. While the aforementioned factors are well associated with risk of infection,

their role in progression from infection to severe sepsis among obstetric patients has not been systematically examined. Indeed, the changes in the frequency of the aforementioned risk factors over time among the patients reported by Bauer et al. [33] have not been reported and require further study. Only a few studies on the relative development of PASS across different phases of pregnancy have been reported and varied markedly across cohorts. selleck inhibitor PASS related to abortion was reported in 6% [27] to 7% [35]. Development of PASS during the antepartum period occurred between 33% [30] and 73% [35], while postpartum PASS events were noted to account for 20% [35] and up to 92.9% [29] of all PASS events. The marked differences in the relative occurrence of PASS across different phases and outcomes of pregnancy reported in the aforementioned studies likely reflects unique local population characteristics, selection bias, and the small Acetophenone sample size. Further larger population-level studies are needed to better understand the risk of PASS across

non-delivery phases of pregnancy. The demographic characteristics of women developing PASS varied with the studied populations. The average age reported ranged from 25.8 years [27] to 32 years [30]. The rate of PASS event in teens and among women older than 34 years was described infrequently, reported in 13.6% and 19.9%, respectively [33]. Black women constituted between 7.1% [29] and 56% [27] of PASS cohorts in local studies and between about 9% [32] and 21.2% [33] in population-level reports, while Hispanic women were reported in 13% [35] and 56.4% [32] of PASS events, reflecting regional variations. Health insurance among US patients with PASS has been reported in two studies. Medicaid was the predominant health insurance (49.8%) of women nationally in the study by Bauer et al. [33], with 3.6% lacking health insurance. Acosta et al. [32] reported the combination of public health insurance/no insurance in 58.2% of PASS hospitalizations.