Six were prescribed naratriptan 2.5 mg tabs, tablet twice daily; one was prescribed frovatriptan 2.5 mg once daily as directed by insurance coverage. All patients and families were instructed to follow the televised or Internet weather forecasts. If a low pressure system was forecast, the families were directed to start the long-acting triptan either the evening or morning before the forecasted pressure drop. The patients were instructed to continue the long-acting triptan for 3 days. They were directed specifically not to take any other triptan medicine while taking the naratriptan or frovatriptan but were told to continue whatever long-term prophylactic therapy they might be taking. As follow-up,

the families were asked to pick one of the following: The long-acting triptan significantly helped the weather related headache The long-acting triptan had little or no effect on the weather related headache The long-acting triptan made the headache worse. The follow-up check details survey was either performed face-to-face at a follow-up visit or via email. Six of 7 responded (86%): 5/6 (including the frovatriptan patient) 1/6 0/6 In this admittedly small sample, 83% had a positive response to long-acting triptan therapy and none had a negative response. This suggests that long-acting triptans could be an appropriate therapy

for weather-related PI3K Inhibitor Library migraine exacerbations, and larger trials are indicated to compare versus placebo response. “
“This chapter reviews selected topics of importance in treating female patients with recurrent headache problems, especially migraine, and is organized according to stages of the female reproductive life cycle. These are: 1) menarche and the onset of sexual maturity, a period when decisions about contraception must be made and when menstrually Fluorouracil connected headaches may become apparent; 2) the reproductive years, during which the interaction between pregnancy and headache disorders must be considered; and 3) the peri- and post-menopausal years, during which decisions must

be made about the use of hormone replacement therapies weighing the risks and benefits of headache treatments in the context of coexistent medical problems. “
“Severe short-lasting headaches are rare but very disabling conditions with a major impact on the patients’ quality of life. Following the IHS criteria (1), these headaches broadly divide themselves into those associated with autonomic symptoms, so called trigeminal autonomic cephalalgias (TACs), and those with few or no autonomic symptoms. The TACs include cluster headache, paroxysmal hemicranias, and a syndrome called SUNCT (short lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing). In all of these syndromes, hemispheric head pain and cranial autonomic symptoms are prominent. The paroxysmal hemicranias have, unlike cluster headaches, a very robust response to indomethacin, leading to a notion of indomethacin-sensitive headaches.