“Liver transplantation (LT) is the treatment of choice for end-stage liver disease, but is controversial in patients with human immunodeficiency virus (HIV) infection. Using a prospective cohort of HIV-hepatitis B virus (HBV) coinfected patients transplanted between 2001-2007; outcomes including survival and HBV clinical recurrence were determined. Twenty-two coinfected patients underwent LT; 45% had detectable HBV DNA pre-LT and 72% were receiving anti-HBV drugs with efficacy against lamivudine-resistant
HBV. Post-LT, all patients received hepatitis B immune globulin (HBIG) plus nucleos(t)ide analogues and remained HBsAg negative without clinical evidence of HBV recurrence, with a median follow-up 3.5 years. Low-level HBV viremia (median 108 IU/mL, range 9-789) was intermittently detected
BMS-754807 in 7/13 but not associated with HBsAg detection or ALT elevation. Compared with 20 HBV monoinfected patients on similar HBV prophylaxis and median follow-up of 4.0 years, patient and graft survival were similar: 100% versus 85% in HBV mono- versus coinfected patients (p = 0.08, log rank test). LT is effective for HIV-HBV coinfected patients with complications of cirrhosis, including those who are HBV DNA positive at the time of LT. Combination HBIG and antivirals is effective as prophylaxis with no clinical evidence of HBV Quisinostat manufacturer recurrence but low-level HBV DNA is detectable in similar to 50% of recipients.”
“This paper reports effects of inter-film interactions on static and dynamic magnetization behavior at film edges in magnetic trilayer stripe arrays under transverse applied fields. The trilayers consist of two magnetic
films of Ni(80)Fe(20), 10 nm and 20 nm thick that interact via dipolar fields across thin, nonmagnetic spacers from 1 nm to 20 nm thick. These trilayer films are patterned into stripe arrays by optical interference lithography. Ferromagnetic resonance spectra exhibit separate edge modes that are identified as excitation of edge modes primarily in one magnetic film or the other. When interlayer exchange is negligible, we observe several effects of dipolar edge-edge coupling including shifts of the edge saturation fields and changes in the mode intensity ratio relative to single-film edges. These interaction Tipifarnib mouse effects are reproduced by micromagnetic modeling and explained by simple models. (c) 2011 American Institute of Physics. [doi:10.1063/1.3553388]“
“The purpose of this study is to assess the validity of patient goal achievement in overactive bladder (OAB).
Data were taken from a placebo-controlled randomised trial of transdermal oxybutynin and open label extension study. Face validity was assessed using qualitative analysis. Convergent validity was assessed by comparison with objective symptom improvement. Responsiveness was assessed at 4 s, using the standardised effect size. Reliability was assessed between 4 and 12 weeks of treatment.